Recurrent Fever and Sore Throat

  • Karin Rydenman
  • Stefan Berg
  • Per Wekell


Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA) is the most common autoinflammatory disorder in children in many parts of the world

PFAPA should be considered in patients with a history of regular, most commonly 3–5-days long fever episodes with associated oropharyngeal symptoms

Children with PFAPA are well between episodes and show normal growth and development

PFAPA is a benign disorder that typically resolves spontaneously within 3 to 5 years after onset

Treatment is primarily symptomatic. Episodes occurring at a time inconvenient for the family can be aborted by a single dose of corticosteroids

Tonsillectomy is a treatment option in selected cases


Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome Corticosteroids Colchicine 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Karin Rydenman
    • 1
    • 2
  • Stefan Berg
    • 2
    • 3
  • Per Wekell
    • 1
    • 2
  1. 1.Department of PediatricsNU-Hospital GroupUddevallaSweden
  2. 2.Department of PediatricsSahlgrenska Academy, University of GothenburgGothenburgSweden
  3. 3.Department of Rheumatology and ImmunologyQueen Silvia Children’s HospitalGothenburgSweden

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