Tumors and Malignancies of the Nasal Cavity

  • Aylin Eryilmaz
  • Sema Başak
  • Hideyuki Kawauchi


All of the nasal cavity and paranasal sinus tumors constitute approximately 3% of upper respiratory tract tumors and 1% of all tumors. Tumors originating from the nasal cavity are common among sinonasal tumors. In advanced sinonasal tumors, it may be difficult to make a decision on where the tumor has originated from, and for this reason, nasal cavity tumors are frequently grouped together with paranasal tumors. However, the increasing use of endoscopes for diagnostic purposes has enabled diagnosis of nasal cavity tumors at earlier stages, today. In this chapter, tumors originating from the nasal cavity will be discussed in all aspects. For the nasal cavity, the most common benign tumor is inverted papilloma and the most common malign histological type is squamous cell cancer. Malign melanoma, adenoid cystic carcinoma, and adenocarcinoma are the following tumors. Since many retrospective studies have covered the treatment results of all tumors belonging to the nasal cavity and paranasal sinuses, it is difficult to evaluate the results of the nasal cavity distinctively. Most of the nasal cavity tumors are treated by surgery and RT, with a multidisciplinary approach. While treatment by surgery alone is possible in carefully chosen T1N0 patients, RT is recommended following surgery in other patients. Among patients having advanced staged nasal cavity tumors, the survival rate of patients who had been treated by RT in addition to surgery was determined to be better than those who had received RT only. Therefore, in advanced-stage and squamous cell nasal cavity tumors, in addition to surgery, RT following surgery is suggested. Treatment with RT alone is recommended in early stage, poorly differentiated tumors, and adenocarcinomas.


Nasal cavity Tumors Malign melanoma Adenoid cystic carcinoma Adenocarcinoma 


  1. 1.
    Silverberg E, Grant RN. Cancer statistics, 1970. CA Cancer J Clin. 1970;20(1):11–23.CrossRefGoogle Scholar
  2. 2.
    Dutta R, Dubal PM, Svider PF, Liu JK, Baredes S, Eloy JA. Sinonasal malignancies: a population-based analysis of site-specific incidence and survival. Laryngoscope. 2015;125(11):2491–7. Scholar
  3. 3.
    Mahalingappa YB, Khalil HS. Sinonasal malignancy: presentation and outcomes. J Laryngol Otol. 2014;128(7):654–7. Scholar
  4. 4.
    Turner JH, Reh DD. Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck. 2012;34(6):877–85. Scholar
  5. 5.
    Weymuller EA, et al. Neoplasms of the nasal cavity. In: Cummings CW, Harker LA, et al., editors. Otolaryngology – head and neck surgery. 4th ed. Maryland Heights, MI: Mosby; 2005.Google Scholar
  6. 6.
    Mayr SI, Hafizovic K, Waldfahrer F, Iro H, Kutting B. Characterization of initial clinical symptoms and risk factors for sinonasal adenocarcinomas: results of a case-control study. Int Arch Occup Environ Health. 2010;83(6):631–8. Scholar
  7. 7.
    Caplan LS, Hall HI, Levine RS, Zhu K. Preventable risk factors for nasal cancer. Ann Epidemiol. 2000;10(3):186–91.CrossRefGoogle Scholar
  8. 8.
    Benninger MS. The impact of cigarette smoking and environmental tobacco smoke on nasal and sinus disease: a review of the literature. Am J Rhinol. 1999;13(6):435–8.CrossRefGoogle Scholar
  9. 9.
    Doll R, Morgan LG, Speizer FE. Cancers of the lung and nasal sinuses in nickel workers. Br J Cancer. 1970;24(4):623–32.CrossRefGoogle Scholar
  10. 10.
    Hayes RB. The carcinogenicity of metals in humans. Cancer Causes Control. 1997;8(3):371–85.CrossRefGoogle Scholar
  11. 11.
    IARC monographs on the evaluation of carcinogenic risks to humans/World Health Organization. Formaldehyde, vol. 62. Lyon: International Agency for Research on Cancer; 1995. p. 217–375.Google Scholar
  12. 12.
    Bruschweiler ED, Hopf NB, Wild P, Huynh CK, Fenech M, Thomas P, Hor M, Charriere N, Savova-Bianchi D, Danuser B. Workers exposed to wood dust have an increased micronucleus frequency in nasal and buccal cells: results from a pilot study. Mutagenesis. 2014;29(3):201–7. Scholar
  13. 13.
    Moon IJ, Lee DY, Suh MW, Han DH, Kim ST, Min YG, Lee CH, Rhee CS. Cigarette smoking increases risk of recurrence for sinonasal inverted papilloma. Am J Rhinol Allergy. 2010;24(5):325–9. Scholar
  14. 14.
    Laco J, Sieglova K, Vosmikova H, Dundr P, Nemejcova K, Michalek J, Celakovsky P, Chrobok V, Mottl R, Mottlova A, Tucek L, Slezak R, Chmelarova M, Sirak I, Vosmik M, Ryska A. The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis. Virchows Arch. 2015;467(4):405–15. Scholar
  15. 15.
    Scheel A, Lin GC, McHugh JB, Komarck CM, Walline HM, Prince ME, Zacharek MA, Carey TE. Human papillomavirus infection and biomarkers in sinonasal inverted papillomas: clinical significance and molecular mechanisms. Int Forum Allergy Rhinol. 2015;5(8):701–7. Scholar
  16. 16.
    Gray ST, Herr MW, Sethi RK, Diercks G, Lee L, Curry W, Chan A, Clark J, Holbrook EH, Rocco J, Sadow PM, Lin DT. Treatment outcomes and prognostic factors, including human papillomavirus, for sinonasal undifferentiated carcinoma: a retrospective review. Head Neck. 2015;37(3):366–74. Scholar
  17. 17.
    Bhattacharyya N. Cancer of the nasal cavity: survival and factors influencing prognosis. Arch Otolaryngol Head Neck Surg. 2002;128(9):1079–83.CrossRefGoogle Scholar
  18. 18.
    Grabovac S, Hadzibegovic AD, Markesic J. Inferior turbinate osteoma as a cause of unilateral nose obstruction. Coll Antropol. 2012;36(Suppl 2):189–91.PubMedGoogle Scholar
  19. 19.
    Scierski W, Namyslowski G, Misiolek M, Widziszowska A, Hajduk A. Septal nasal chondroma--a case report. Otolaryngol Pol. 2007;61(6):1021–3. Scholar
  20. 20.
    Butugan O, Sanchez TG, Balbani AP, da Silveira JA, Miniti A, Zerbini MC. Nasal chondroma: a case report and review of the literature. Rev Laryngol Otol Rhinol (Bord). 1997;118(3):199–201.Google Scholar
  21. 21.
    Kumar S, Dar NH, Ashraf M, Sharma SC, Maheshwari V. Ossifying fibroma of nose in a two year old child. Indian J Otolaryngol Head Neck Surg. 2004;56(1):37–9. Scholar
  22. 22.
    Hasturk AE, Basmaci M, Bayram C, Bozdogan N. Surgical management of recurrent malignant schwannoma of the scalp. J Craniofac Surg. 2011;22(3):1120–2. Scholar
  23. 23.
    Shugar JM, Som PM, Biller HF, Som ML, Krespi YP. Peripheral nerve sheath tumors of the paranasal sinuses. Head Neck Surg. 1981;4(1):72–6.CrossRefGoogle Scholar
  24. 24.
    Bhattacharyya N, Wenokur RK, Goodman ML. Endoscopic excision of a giant pyogenic granuloma of the nasal cavity caused by nasal packing. Rhinology. 1997;35(1):44–5.PubMedGoogle Scholar
  25. 25.
    Simic R, Vlahovic A, Subarevic V. Treatment of nasal hemangiomas. Int J Pediatr Otorhinolaryngol. 2009;73(10):1402–6. Scholar
  26. 26.
    Baptista MA, Pinna Fde R, Voegels RL. Extranasopharyngeal angiofibroma originating in the inferior turbinate: a distinct clinical entity at an unusual site. Int Arch Otorhinolaryngol. 2014;18(4):403–5. Scholar
  27. 27.
    Melroy CT, Senior BA. Benign sinonasal neoplasms: a focus on inverting papilloma. Otolaryngol Clin N Am. 2006;39(3):601–617, x. Scholar
  28. 28.
    Lee DK, Chung SK, Dhong HJ, Kim HY, Kim HJ, Bok KH. Focal hyperostosis on CT of sinonasal inverted papilloma as a predictor of tumor origin. AJNR Am J Neuroradiol. 2007;28(4):618–21.PubMedGoogle Scholar
  29. 29.
    Jeon TY, Kim HJ, Chung SK, Dhong HJ, Kim HY, Yim YJ, Kim ST, Jeon P, Kim KH. Sinonasal inverted papilloma: value of convoluted cerebriform pattern on MR imaging. AJNR Am J Neuroradiol. 2008;29(8):1556–60. Scholar
  30. 30.
    Murphy JT, Chandran A, Strachan DR, Sood S. Bilateral inverted papilloma: a report of two cases and review of the current literature. Indian J Otolaryngol Head Neck Surg. 2010;62(3):313–6. Scholar
  31. 31.
    Sautter NB, Citardi MJ, Batra PS. Minimally invasive resection of frontal recess/sinus inverted papilloma. Am J Otolaryngol. 2007;28(4):221–4. Scholar
  32. 32.
    Gras-Cabrerizo JR, Montserrat-Gili JR, Massegur-Solench H, Leon-Vintro X, De Juan J, Fabra-Llopis JM. Management of sinonasal inverted papillomas and comparison of classification staging systems. Am J Rhinol Allergy. 2010;24(1):66–9. Scholar
  33. 33.
    Yu HX, Liu G. Malignant transformation of sinonasal inverted papilloma: a retrospective analysis of 32 cases. Oncol Lett. 2014;8(6):2637–41. Scholar
  34. 34.
    von Buchwald C, Bradley PJ. Risks of malignancy in inverted papilloma of the nose and paranasal sinuses. Curr Opin Otolaryngol Head Neck Surg. 2007;15(2):95–8. Scholar
  35. 35.
    Mansell NJ, Bates GJ. The inverted Schneiderian papilloma: a review and literature report of 43 new cases. Rhinology. 2000;38(3):97–101.PubMedGoogle Scholar
  36. 36.
    Healy DY Jr, Chhabra N, Metson R, Holbrook EH, Gray ST. Surgical risk factors for recurrence of inverted papilloma. Laryngoscope. 2016;126(4):796–801. Scholar
  37. 37.
    Choi JW, Kim SG, Kim YM, Yoon YH, Kim AY, Rha KS. Clinical and histologic features of inverted papilloma-associated malignancy. Eur Arch Otorhinolaryngol. 2012;269(11):2349–54. Scholar
  38. 38.
    Gajda M, Zagolski O, Jasztal A, Lis GJ, Pyka-Fosciak G, Jan AL. Respiratory epithelial adenomatoid hamartoma of the anterior nasal septum a rare localisation of an unusual tumour in a child: a case report. Cases J. 2009;2:8151. Scholar
  39. 39.
    Seol JG, Livolsi VA, O’Malley BW Jr, Chen JY, Loevner LA. Respiratory epithelial adenomatoid hamartoma of the bilateral olfactory recesses: a neoplastic mimic? AJNR Am J Neuroradiol. 2010;31(2):277–9. Scholar
  40. 40.
    Lima NB, Jankowski R, Georgel T, Grignon B, Guillemin F, Vignaud JM. Respiratory adenomatoid hamartoma must be suspected on CT-scan enlargement of the olfactory clefts. Rhinology. 2006;44(4):264–9.PubMedGoogle Scholar
  41. 41.
    Kida A, Endo S, Iida H, Yamada Y, Sakai F, Furusaka T, Ishiyama K. Clinical assessment of squamous cell carcinoma of the nasal cavity proper. Auris Nasus Larynx. 1995;22(3):172–7.CrossRefGoogle Scholar
  42. 42.
    Lupinetti AD, Roberts DB, Williams MD, Kupferman ME, Rosenthal DI, Demonte F, El-Naggar A, Weber RS, Hanna EY. Sinonasal adenoid cystic carcinoma: the M. D. Anderson Cancer Center experience. Cancer. 2007;110(12):2726–31. Scholar
  43. 43.
    Amit M, Binenbaum Y, Sharma K, Ramer N, Ramer I, Agbetoba A, Miles B, Yang X, Lei D, Bjoerndal K, Godballe C, Mucke T, Wolff KD, Fliss D, Eckardt AM, Copelli C, Sesenna E, Palmer F, Patel S, Gil Z. Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: a meta-analysis. J Neurol Surg B Skull Base. 2013;74(3):118–25. Scholar
  44. 44.
    Szanto PA, Luna MA, Tortoledo ME, White RA. Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer. 1984;54(6):1062–9.CrossRefGoogle Scholar
  45. 45.
    Rhee CS, Won TB, Lee CH, Min YG, Sung MW, Kim KH, Shim WS, Kim YM, Kim JW. Adenoid cystic carcinoma of the sinonasal tract: treatment results. Laryngoscope. 2006;116(6):982–6. Scholar
  46. 46.
    Fordice J, Kershaw C, El-Naggar A, Goepfert H. Adenoid cystic carcinoma of the head and neck: predictors of morbidity and mortality. Arch Otolaryngol Head Neck Surg. 1999;125(2):149–52.CrossRefGoogle Scholar
  47. 47.
    Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Hinerman RW, Villaret DB. Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck. Head Neck. 2004;26(2):154–62. Scholar
  48. 48.
    Marcus DM, Marcus RP, Prabhu RS, Owonikoko TK, Lawson DH, Switchenko J, Beitler JJ. Rising incidence of mucosal melanoma of the head and neck in the United States. J Skin Cancer. 2012;2012:231693. Scholar
  49. 49.
    Lietin B, Montalban A, Louvrier C, Kemeny JL, Mom T, Gilain L. Sinonasal mucosal melanomas. Eur Ann Otorhinolaryngol Head Neck Dis. 2010;127(2):70–6. Scholar
  50. 50.
    Khan MK, Khan N, Almasan A, Macklis R. Future of radiation therapy for malignant melanoma in an era of newer, more effective biological agents. Onco Targets Ther. 2011;4:137–48. Scholar
  51. 51.
    Patel TD, Carniol ET, Vazquez A, Baredes S, Liu JK, Eloy JA. Sinonasal fibrosarcoma: analysis of the surveillance, epidemiology, and end results database. Int Forum Allergy Rhinol. 2015;6(2):201–5. Scholar
  52. 52.
    Kharrat S, Sahtout S, Tababi S, Temimi S, Ben Miled M, Abid W, Zainine R, Nouira K, Menif E, Beltaief N, Besbes G. Chondrosarcoma of sinonasal cavity: a case report and brief literature review. Tunis Med. 2010;88(2):122–4.PubMedGoogle Scholar
  53. 53.
    Steinbichler TB, Kral F, Reinold S, Riechelmann H. Chondrosarcoma of the nasal cavity in a patient with Maffucci syndrome: case report and review of the literature. World J Surg Oncol. 2014;12:387. Scholar
  54. 54.
    Dai X, Ma W, He X, Jha RK. Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing’s sarcoma. Med Sci Monit. 2011;17(8):RA177–90.CrossRefGoogle Scholar
  55. 55.
    Xu G, He G, Liu B, Xu Z. Clinical analysis of 5 cases with hemangiopericytoma in nasal cavity and paranasal sinuses. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014;28(5):314–7.PubMedGoogle Scholar
  56. 56.
    Ugur Duman F, Ayhan S, Isisag A, Eskiizmir G, Tarhan S. Sinonasal-type haemangiopericytoma: a case reportTurk Patoloji Derg. 2015;31(1):72–6. Scholar
  57. 57.
    Zhu L, Fang P, Liu Y, Tong B. Clinical and diagnosis analysis of malignant lymphoma in nasal cavity and paranasal sinus. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015;29(3):255–7.PubMedGoogle Scholar
  58. 58.
    Ashraf MJ, Azarpira N, Khademi B, Abedi E, Hakimzadeh A, Valibeigi B. Extramedullary plasmacytoma of the nasal cavity report of three cases with review of the literature. Iran Red Crescent Med J. 2013;15(4):363–6. Scholar
  59. 59.
    Bachar G, Goldstein D, Brown D, Tsang R, Lockwood G, Perez-Ordonez B, Irish J. Solitary extramedullary plasmacytoma of the head and neck--long-term outcome analysis of 68 cases. Head Neck. 2008;30(8):1012–9. Scholar
  60. 60.
    Jackson RT, Fitz-Hugh GS, Constable WC. Malignant neoplasms of the nasal cavities and paranasal sinuses: (a retrospective study). Laryngoscope. 1977;87(5. Pt 1):726–36.CrossRefGoogle Scholar
  61. 61.
    Zimmer LA, Carrau RL. Neoplasms of the nose and paranasal sinuses. In: Bailey BJ, Johnson JT, Newland SD, editors. Head & neck surgery – otolaryngology. 4th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2006.Google Scholar
  62. 62.
    Sivalingam J, Sarawagi R, Raghuwanshi S, Yadav PK. Sinonasal neoplasia – Clinicopathological profile and importance of computed tomography. J Clin Diagn Res. 2015;9(6):TC01–4. Scholar
  63. 63.
    Gomaa MA, Hammad MS, Abdelmoghny A, Elsherif AM, Tawfik HM. Magnetic resonance imaging versus computed tomography and different imaging modalities in evaluation of sinonasal neoplasms diagnosed by histopathology. Clin Med Insights Ear Nose Throat. 2013;6:9–15. Scholar
  64. 64.
    Fujima N, Nakamaru Y, Sakashita T, Homma A, Tsukahara A, Kudo K, Shirato H. Differentiation of squamous cell carcinoma and inverted papilloma using non-invasive MR perfusion imaging. Dentomaxillofac Radiol. 2015;44(9):20150074. Scholar
  65. 65.
    Guntinas-Lichius O, Kreppel MP, Stuetzer H, Semrau R, Eckel HE, Mueller RP. Single modality and multimodality treatment of nasal and paranasal sinuses cancer: a single institution experience of 229 patients. Eur J Surg Oncol. 2007;33(2):222–8. Scholar
  66. 66.
    Homma A, Nakamaru Y, Sakashita T, Onimaru R, Terasaka S, Tsuchiya K, Yoshida D, Yasuda K, Hatakeyama H, Furusawa J, Mizumachi T, Kano S, Shirato H, Fukuda S. Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus: a single institution experience. Auris Nasus Larynx. 2015;42(5):377–81. Scholar
  67. 67.
    Hu WH, Xie FY, Chen DZ, Wu Y, Jiao JJ, Peng WJ, Yan C, Fang SH. Prognosis and treatment for 98 patients with carcinoma of nasal cavity. Ai Zheng. 2004;23(11 Suppl):1542–5.PubMedGoogle Scholar
  68. 68.
    Wang K, Shang J, Xu Y. Treatment of cancer of the nasal cavity in 128 casesZhonghua Er Bi Yan Hou Ke Za Zhi. 2000;35(3):168–71.PubMedGoogle Scholar
  69. 69.
    Cansz H, Tahamiler R, Yener M, Acoglu E, Guvenc MG, Papila I, Sekercioglu N. Modified midfacial degloving approach for sinonasal tumors. J Craniofac Surg. 2008;19(6):1518–22. Scholar
  70. 70.
    Valentini V, Terenzi V, Bartoli D, Battisti A, Aboh IV, Egidi S, Cassoni A. Single-step nasal reconstruction with osteocutaneous forearm flap after total rhinectomy. J Craniofac Surg. 2012;23(5):e474–6. Scholar
  71. 71.
    Hamahata A, Saitou T, Beppu T, Yamaki T, Sakurai H. A new nasal cavity and maxilla reconstruction method using jejunum flap with non-vascularised bone. J Plast Reconstr Aesthet Surg. 2013;66(1):e12–5. Scholar
  72. 72.
    Hanna E, DeMonte F, Ibrahim S, Roberts D, Levine N, Kupferman M. Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results. Arch Otolaryngol Head Neck Surg. 2009;135(12):1219–24. Scholar
  73. 73.
    Khademi B, Moradi A, Hoseini S, Mohammadianpanah M. Malignant neoplasms of the sinonasal tract: report of 71 patients and literature review and analysis. Oral Maxillofac Surg. 2009;13(4):191–9. Scholar
  74. 74.
    Swegal W, Koyfman S, Scharpf J, Sindwani R, Greskovich J, Borden E, Burkey BB. Endoscopic and open surgical approaches to locally advanced sinonasal melanoma: comparing the therapeutic benefits. JAMA Otolaryngol Head Neck Surg. 2014;140(9):840–5. Scholar
  75. 75.
    Hadad G, Bassagasteguy L, Carrau RL, Mataza JC, Kassam A, Snyderman CH, Mintz A. A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap. Laryngoscope. 2006;116(10):1882–6. Scholar
  76. 76.
    Hoppe BS, Wolden SL, Zelefsky MJ, Mechalakos JG, Shah JP, Kraus DH, Lee N. Postoperative intensity-modulated radiation therapy for cancers of the paranasal sinuses, nasal cavity, and lacrimal glands: technique, early outcomes, and toxicity. Head Neck. 2008;30(7):925–32. Scholar
  77. 77.
    Eich HT, Staar S, Micke O, Eich PD, Stutzer H, Muller R. Radiotherapy of esthesioneuroblastoma. Int J Radiat Oncol Biol Phys. 2001;49(1):155–60.CrossRefGoogle Scholar
  78. 78.
    Abe T, Ebara T, Miyaura K, Kumazaki Y, Nakahira M, Sugasawa M, Shikama N, Kato S. Malignant melanoma of the nasal cavity treated with stereotactic radiotherapy using CyberKnife: report of 2 cases. Am J Otolaryngol. 2015;36(2):306–9. Scholar
  79. 79.
    Llorente JL, Lopez F, Suarez C, Hermsen MA. Sinonasal carcinoma: clinical, pathological, genetic and therapeutic advances. Nat Rev Clin Oncol. 2014;11(8):460–72. Scholar
  80. 80.
    Rischin D, Porceddu S, Peters L, Martin J, Corry J, Weih L. Promising results with chemoradiation in patients with sinonasal undifferentiated carcinoma. Head Neck. 2004;26(5):435–41. Scholar
  81. 81.
    Katz TS, Mendenhall WM, Morris CG, Amdur RJ, Hinerman RW, Villaret DB. Malignant tumors of the nasal cavity and paranasal sinuses. Head Neck. 2002;24(9):821–9. Scholar
  82. 82.
    Hu W, Xie F, Chen D, Chen M, He D, Mao Z, Pan G. Prognostic factors of 60 nasal cavity carcinoma patientsZhonghua Zhong Liu Za Zhi. 2002;24(6):592–4.PubMedGoogle Scholar
  83. 83.
    Fornelli RA, Fedok FG, Wilson EP, Rodman SM. Squamous cell carcinoma of the anterior nasal cavity: a dual institution review. Otolaryngol Head Neck Surg. 2000;123(3):207–10. Scholar
  84. 84.
    Agger A, von Buchwald C, Madsen AR, Yde J, Lesnikova I, Christensen CB, Foghsgaard S, Christensen TB, Hansen HS, Larsen S, Bentzen J, Andersen E, Andersen L, Grau C. Squamous cell carcinoma of the nasal vestibule 1993-2002: a nationwide retrospective study from DAHANCA. Head Neck. 2009;31(12):1593–9. Scholar
  85. 85.
    Wang CC. Treatment of carcinoma of the nasal vestibule by irradiation. Cancer. 1976;38(1):100–6.CrossRefGoogle Scholar
  86. 86.
    Wallace A, Morris CG, Kirwan J, Amdur RJ, Werning JW, Mendenhall WM. Radiotherapy for squamous cell carcinoma of the nasal vestibule. Am J Clin Oncol. 2007;30(6):612–6. Scholar
  87. 87.
    Talmi YP, Ferlito A, Takes RP, Strojan P, Langendijk JA, Shaha AR, Rinaldo A. Lymph node metastasis in nasal vestibule cancer: a review. Head Neck. 2011;33(12):1783–8. Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Aylin Eryilmaz
    • 1
  • Sema Başak
    • 1
  • Hideyuki Kawauchi
    • 2
  1. 1.Department of Otorhinolaryngology, Medical FacultyAdnan Menderes UniversityAydınTurkey
  2. 2.Faculty of Medicine, Department of OtorhinolaryngologyShimane UniversityShimaneJapan

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