Acute Viral Rhinitis

  • Tolgahan Çatlı
  • Huntürk Atilla
  • Eva Kathryn Miller


Rhinitis refers to any kind of inflammatory condition of the nasal mucosal linings. Generally, acute rhinitis is associated with environmental allergies or respiratory viral infections. Viral microbes with numerous types and subtypes can infect the respiratory epithelium of the nasal cavity in a repetitive fashion throughout the year, or during a specific period of time such as winter or fall. Among all forms of inflammatory diseases of the nasal mucosa, acute viral rhinitis (AVR) has unique epidemiological, clinical, and therapeutic characteristics. As the most prevalent type of rhinitis, AVR is also the most common form of any infectious disease of the human body. Although it is almost always self-limiting, in rare circumstances disease might progress and the clinical scenario could become complicated. Common complaints and physical findings related to AVR are similar to those seen with other types of rhinitis such as allergic, hormonal, senile, or drug induced. The clinician must interpret these symptoms and findings in the context of other parameters such as “duration, environmental factors, and patient characteristics” to establish an accurate diagnose and appropriate therapeutic management. In this chapter, we aim to discuss the epidemiology, pathogenesis, clinical findings, differential diagnosis, and therapeutic management of AVR in light of the recent literature knowledge. It is our hope that this chapter may aid medical professionals who encounter AVR in daily practice.


Acute viral rhinitis Rhinitis Inflammatory Epidemiology Pathogenesis Clinical findings 


  1. 1.
    Slavin RG, Spector SL, Bernstein IL, et al. The diagnosis and management of sinusitis: a practice parameter update. J Allergy Clin Immunol. 2005;116:S13–47.CrossRefGoogle Scholar
  2. 2.
    Yan Y, Gordon WM, Wang DY. Nasal epithelial repair and remodeling in physical injury, infection, and inflammatory diseases. Curr Opin Otolaryngol Head Neck Surg. 2013;21(3):263–70.CrossRefGoogle Scholar
  3. 3.
    Winther B, Gwaltney JM Jr, Mygind N, et al. Viral-induced rhinitis. Am J Rhinol. 1998;12(1):17–20.CrossRefGoogle Scholar
  4. 4.
    Dingle JH, Badger GF, Jordan WS Jr. lIIness in the home. A study of 25,000 illnesses in a group of Cleveland families. Cleveland: The Press of Western Reserve University; 1964.Google Scholar
  5. 5.
    Winther B, Gwaltney JM Jr, Mygind N, et al. Sites of rhinovirus recovery after point-inoculation of the upper airway. JAMA. 1986;256:1763–7.CrossRefGoogle Scholar
  6. 6.
    Watelet JB, Van Zele T, Gjomarkaj M, et al. Tissue remodelling in upper airways: where is the link with lower airway remodelling? Allergy. 2006;61:1249–58.CrossRefGoogle Scholar
  7. 7.
    Fokkens WJ, Lund VJ, Mullol J, et al. European position paper on rhinosinusitisand nasal polyps. Rhinol Suppl. 2012;23:1–298.Google Scholar
  8. 8.
    Papi A, Johnston SL. Rhinovirus infection induces expression of its own receptor intercellular adhesion molecule 1 (ICAM-1) via increased NF-kappaB-mediated transcription. J Biol Chem. 1999;274:9707–20.CrossRefGoogle Scholar
  9. 9.
    Lewis TC, Henderson TA, Carpenter AR, et al. Nasal cytokine responses to natural colds in asthmatic children. Clin Exp Allergy. 2012;42:1734–44.CrossRefGoogle Scholar
  10. 10.
    Van Kempen M, Bachert C, Van Cauwenberge P. An update on the patho-physiology of rhinovirus upper respiratory tract infections. Rhinology. 1999;37:97–103.PubMedGoogle Scholar
  11. 11.
    Quillen DM, Feller DB. Diagnosing rhinitis: allergic vs. nonallergic. Am Fam Physician. 2006;73(9):1583–90.PubMedGoogle Scholar
  12. 12.
    Doyle WJ, Gentile A, Skoner D. Viral and bacterial rhinitis. Clin Allergy Immunol. 2007;19:177–95.PubMedGoogle Scholar
  13. 13.
    Doyle WJ. Illness and otological changes during upper respiratory virus infection. Laryngoscope. 1999;109:324–8.CrossRefGoogle Scholar
  14. 14.
    Doyle WJ, Skoner DP, Gentile D. Nasal cytokines as mediators of illness during the common cold. Curr Allergy Asthma Rep. 2005;5(3):173–81.CrossRefGoogle Scholar
  15. 15.
    Bende M. Changes in human nasal mucosa during experimental coronavirus common colds. Acta Otolaryngol. 1989;107(3–4):262–9.CrossRefGoogle Scholar
  16. 16.
    Hedrick JA. Zanamivir for treatment of symptomatic influenza A and B infection in children five to twelve years of age: a randomized controlled trial. Pediatr Infect Dis J. 2000;19(5):410–7.CrossRefGoogle Scholar
  17. 17.
    Fendrick AM. Viral respiratory infections due to rhinoviruses: current knowledge, new developments. Am J Ther. 2003;10(3):193–202.CrossRefGoogle Scholar
  18. 18.
    Doyle WJ. Effect of rimantadine treatment on clinical manifestations and otologic complications in adults experimentally infected with influenza A (H1N1) virus. J Infect Dis. 1998;177(5):1260–5.CrossRefGoogle Scholar
  19. 19.
    Kibble A. 18th International Conference on Antiviral Research. Respiratory viruses. Drugs. 2005;8(6):465–6.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Tolgahan Çatlı
    • 1
  • Huntürk Atilla
    • 2
  • Eva Kathryn Miller
    • 3
  1. 1.Department of OtorhinolaryngologyUniversity of Health Sciences, Bozyaka Training and Research HospitalİzmirTurkey
  2. 2.Department of OtorhinolaryngologyUniversity of Health Sciences, Yenimahalle Training and Research HospitalAnkaraTurkey
  3. 3.Department of PediatricsVanderbilt University School of MedicineNashvilleUSA

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