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Infantile Rhinitis

  • Ozge Yilmaz
  • Hasan Yuksel
  • Derya Altıntaş
Chapter

Abstract

Rhinitis is nasal inflammation associated with symptoms of nasal discharge, obstruction, and itching, as well as sneezing; the term AR (AR) is used when these pathogenetic and clinical symptoms are attributed to sensitization to an allergen. When these clinical findings are observed in children younger than 2 years of age, the condition is classified as “infantile rhinitis.” Rhinitis in infants has a long list of differential diagnoses including infections and congenital anatomic lesions as well as multisystem diseases such as cystic fibrosis; however, we now know that AR can be defined in this age group, too, enlarging the list of differential diagnoses. It has been reported that AR symptoms have been observed at ages as early as 6 months. The prevalence of AR, which is one of the most common chronic diseases both in adults and children, varies widely, from 10 to 40%, and this prevalence seems to be increasing in most countries in the world. However, AR was not considered to be a major problem in infants. This concept has changed over the years, and we now know that allergy may also be a cause of rhinitis in infants. There are many risk factors associated with infantile rhinitis; many others are known for the development of allergy. It has been demonstrated that living in houses with high mold exposure and not having an older sibling are associated with frequent infectious rhinitis in infants. Moreover, exposure to environmental tobacco smoke is a risk factor for the development of allergic and non-allergic rhinitis. In this chapter, infantile rhinitis is discussed in all aspects.

Keywords

Infantile rhinitis Infectious rhinitis Exposure to environmental tobacco smoke Cystic fibrosis Nasal inflammation 

References

  1. 1.
    Roberts G, Xatzipsalti M, Borrego LM, et al. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013;68:1102–16.PubMedPubMedCentralGoogle Scholar
  2. 2.
    Herr M, Clarisse B, Nikasinovic L, et al. Does allergic rhinitis exist in infancy? Findings from the PARIS birth cohort. Allergy. 2011;66:214–21.PubMedGoogle Scholar
  3. 3.
    Babinski D, Trawinska-Bartnicka M. Rhinosinusitis in cystic fibrosis: not a simple story. Int J Pediatr Otorhinolaryngol. 2008;72:619–24.PubMedGoogle Scholar
  4. 4.
    Mercer MJ, van der Linde GP, Joubert G. Rhinitis (allergic and nonallergic) in an atopic pediatric referral population in the grasslands of inland South Africa. Ann Allergy Asthma Immunol. 2002;89:503–12.PubMedGoogle Scholar
  5. 5.
    Weinmayr G, Forastiere F, Weiland SK, et al. International variation in prevalence of rhinitis and its relationship with sensitisation to perennial and seasonal allergens. Eur Respir J. 2008;32:1250–61.PubMedGoogle Scholar
  6. 6.
    Yu YM, Chan YH, Calder PC, et al. Maternal PUFA status and offspring allergic diseases up to the age of 18 months. Br J Nutr. 2015;113:975–83.PubMedGoogle Scholar
  7. 7.
    Yuksel H, Dinc G, Sakar A, et al. Prevalence and comorbidity of allergic eczema, rhinitis, and asthma in a city in western Turkey. J Investig Allergol Clin Immunol. 2008;18:31–5.PubMedGoogle Scholar
  8. 8.
    Bayram I, Güneşer-Kendirli S, Yilmaz M, et al. The prevalence of asthma and allergic diseases in children of school age in Adana in southern Turkey. Turk J Pediatr. 2004;46:221–5.PubMedGoogle Scholar
  9. 9.
    Björkstén B, Clayton T, Ellwood P, et al. Worldwide time trends for symptoms of rhinitis and conjunctivitis: phase III of the International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immunol. 2008;19:110–24.PubMedGoogle Scholar
  10. 10.
    Civelek E, Yavuz ST, Boz AB, et al. Epidemiology and burden of rhinitis and rhinoconjunctivitis in 9- to 11-year-old children. Am J Rhinol Allergy. 2010;24:364–70.PubMedGoogle Scholar
  11. 11.
    Ballardini N, Kull I, Lind T, et al. Development and comorbidity of eczema, asthma and rhinitis to age 12: data from the BAMSE birth cohort. Allergy. 2012;67:537–44.PubMedGoogle Scholar
  12. 12.
    Osawa Y, Suzuki D, Ito Y, et al. Prevalence of inhaled antigen sensitization and nasal eosinophils in Japanese children under two years old. Int J Pediatr Otorhinolaryngol. 2012;76:189–93.PubMedGoogle Scholar
  13. 13.
    Rancière F, Nikasinovic L, Bousquet J, et al. Onset and persistence of respiratory/allergic symptoms in preschoolers: new insights from the PARIS birth cohort. Allergy. 2013;68:1158–67.PubMedGoogle Scholar
  14. 14.
    Biagini JM, LeMasters GK, Ryan PH, et al. Environmental risk factors of rhinitis in early infancy. Pediatr Allergy Immunol. 2006;17:278–84.PubMedPubMedCentralGoogle Scholar
  15. 15.
    Martel MJ, Beauchesne MF, Malo JL, et al. Maternal asthma, its control and severity in pregnancy, and the incidence of atopic dermatitis and allergic rhinitis in the offspring. J Pediatr. 2009;155:707–13.PubMedGoogle Scholar
  16. 16.
    Arshad SH, Tariq SM, Matthews S, et al. Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study. Pediatrics. 2001;108:E33.PubMedGoogle Scholar
  17. 17.
    Kulig M, Klettke U, Wahn V, et al. Development of seasonal allergic rhinitis during the first 7 years of life. J Allergy Clin Immunol. 2010;106:832–9.Google Scholar
  18. 18.
    Rodrigues F, Foster D, Nicoli E, et al. Relationships between rhinitis symptoms, respiratory viral infections and nasopharyngeal colonization with Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in children attending daycare. Pediatr Infect Dis J. 2013;32:227–32.PubMedGoogle Scholar
  19. 19.
    Oguonu T, Adaeze Ayuk C, Edelu BO, et al. Pattern of respiratory diseases in children presenting to the paediatric emergency unit of the University of Nigeria Teaching Hospital, Enugu: a case series report. BMC Pulm Med. 2014;14:101.PubMedPubMedCentralGoogle Scholar
  20. 20.
    Miller EK, Williams JV, Gebretsadik T, et al. Host and viral factors associated with severity of human rhinovirus-associated infant respiratory tract illness. J Allergy Clin Immunol. 2011;127:883–91.PubMedPubMedCentralGoogle Scholar
  21. 21.
    Utokaparch S, Marchant D, Gosselink JV, et al. The relationship between respiratory viral loads and diagnosis in children presenting to a pediatric hospital emergency department. Pediatr Infect Dis J. 2011;30:e18–23.PubMedGoogle Scholar
  22. 22.
    Scadding GK. Optimal management of allergic rhinitis. Arch Dis Child. 2015;100:576–82.PubMedPubMedCentralGoogle Scholar
  23. 23.
    Moussu L, Saint-Pierre P, Panayotopoulos V, et al. Determinants of allergic rhinitis in young children with asthma. PLoS One. 2014;9:e97236.PubMedPubMedCentralGoogle Scholar
  24. 24.
    Sih T, Mion O. Allergic rhinitis in the child and associated comorbidities. Pediatr Allergy Immunol. 2010;21:e107–13.PubMedGoogle Scholar
  25. 25.
    Loeffelholz MJ, Trujillo R, Pyles RB, et al. Duration of rhinovirus shedding in the upper respiratory tract in the first year of life. Pediatrics. 2014;134:1144–50.PubMedPubMedCentralGoogle Scholar
  26. 26.
    Baatenburg de Jong A, Dikkeschei LD, Brand PL. High prevalence of sensitization to aeroallergens in children 4 yrs of age or younger with symptoms of allergic disease. Pediatr Allergy Immunol. 2009;20:735–40.PubMedGoogle Scholar
  27. 27.
    Davis SD, Ferkol TW, Rosenfeld M, et al. Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype. Am J Respir Crit Care Med. 2015;191:316–24.PubMedPubMedCentralGoogle Scholar
  28. 28.
    Lucas JS, Paff T, Goggin P, et al. Diagnostic methods in primary ciliary dyskinesia. Paediatr Respir Rev. 2016;18:8–17.PubMedGoogle Scholar
  29. 29.
    Gane SB, Scadding GK. Diseases mimicking allergic rhinitis. Pediatr Allergy Immunol. 2010;21:e114–8.PubMedGoogle Scholar
  30. 30.
    Robertson JM, Friedman EM, Rubin BK. Nasal and sinus disease in cystic fibrosis. Paediatr Respir Rev. 2008;9:213–9.PubMedGoogle Scholar
  31. 31.
    Simons FE, Silas P, Portnoy JM. Safety of cetirizine in infants 6 to 11 months of age: a randomized, double-blind, placebo-controlled study. J Allergy Clin Immunol. 2003;111:1244–8.PubMedGoogle Scholar
  32. 32.
    Manica D, Schweiger C, Netto CC, et al. Retrospective study of a series of choanal atresia patients. Int Arch Otorhinolaryngol. 2014;18:2–5.PubMedGoogle Scholar
  33. 33.
    Kwong KM. Current updates on choanal atresia. Front Pediatr. 2015;3:52.PubMedPubMedCentralGoogle Scholar
  34. 34.
    Wald ER. Acute otitis media and acute bacterial sinusitis. Clin Infect Dis. 2011;52:S277–8.PubMedGoogle Scholar
  35. 35.
    Kalu SU, Ataya RS, McCormick DP, et al. Clinical spectrum of acute otitis media complicating upper respiratory tract viral infection. Pediatr Infect Dis J. 2011;30:95–9.PubMedPubMedCentralGoogle Scholar
  36. 36.
    Sedaghat AR, Phipatanakul W, Cunningham MJ. Prevalence of and associations with allergic rhinitis in children with chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol. 2014;78:343–7.PubMedGoogle Scholar
  37. 37.
    Carranza-Martinez MI, Newton-Sanchez O, Franco-Paredes C, et al. Clinical outcomes in Mexican children with febrile acute upper respiratory tract infections: no impact of antibiotic therapy. Int J Infect Dis. 2010;14:e759–63.PubMedGoogle Scholar
  38. 38.
    Simons FE, Early Prevention of Asthma in Atopic Children (EPAAC) Study Group. Safety of levocetirizine treatment in young atopic children: an 18-month study. Pediatr Allergy Immunol. 2007;18:535–42.PubMedGoogle Scholar
  39. 39.
    Chong Neto HJ, Rosário CS, Rosário BA, et al. Allergic rhinitis in preschool children from Southern Brazil. Allergy. 2014;69:545–7.PubMedGoogle Scholar
  40. 40.
    Mainz JG, Schien C, Schiller I, et al. Sinonasal inhalation of dornase alfa administered by vibrating aerosol to cystic fibrosis patients: a double-blind placebo-controlled cross-over trial. J Cyst Fibros. 2014;13:461–70.PubMedGoogle Scholar
  41. 41.
    Di Cicco M, Alicandro G, Claut L, et al. Efficacy and tolerability of a new nasal spray formulation containing hyaluronate and tobramycin in cystic fibrosis patients with bacterial rhinosinusitis. J Cyst Fibros. 2014;13:455–60.PubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Ozge Yilmaz
    • 1
  • Hasan Yuksel
    • 1
  • Derya Altıntaş
    • 2
  1. 1.Department of Pediatric Allergy and Pulmonology, Medical FacultyCelal Bayar UniversityManisaTurkey
  2. 2.Department of Pediatric Allergy, Medical FacultyÇukurova UniversityAdanaTurkey

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