Cardiorenal Syndrome in a Patient with Mechanical Circulatory Support

  • Andrew Xanthopoulos
  • Filippos Triposkiadis
  • Randall C. StarlingEmail author


Cardiovascular diseases are often associated with concomitant or de novo kidney disease. Renal dysfunction is common in patients with advanced heart failure. Although irreversible renal dysfunction and treatment with renal replacement therapy are considered an absolute contraindication to left ventricular assist device (LVAD) implantation as destination therapy, advanced heart failure patients with recent onset renal dysfunction should not be excluded from LVAD treatment when improvement of renal function post LVAD is anticipated. The implantation of LVADs is accompanied by short-term improvements in renal function, whereas data on long-term outcomes is ambiguous. Acute kidney injury (AKI) is not uncommon after LVAD implantation and it is accompanied by high mortality rates. Whether the type of mechanical circulatory support (MCS) device (pulsatile vs non-pulsatile) has a different effect on renal function remains unknown. The emerging role of percutaneous, short-term MCS devices for the restoration or the preservation of renal function is promising.


Advanced heart failure Pathophysiology Renal function Left ventricular assist devices Acute kidney injury Pulsatile Percutaneous Outcomes Improvement 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Andrew Xanthopoulos
    • 1
    • 2
  • Filippos Triposkiadis
    • 2
  • Randall C. Starling
    • 1
    Email author
  1. 1.Department of Cardiovascular MedicineHeart and Vascular Institute, Kaufman Center for Heart Failure, Cleveland ClinicClevelandUSA
  2. 2.Department of CardiologyUniversity General Hospital of LarissaLarissaGreece

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