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Dried Plasma

  • Mouayyad Zaza
  • Kyle J. Kalkwarf
  • John B. Holcomb
Chapter

Abstract

Dried plasma provides an alternative for early plasma transfusion in the resuscitation of hemorrhagic shock in environments where fresh frozen plasma is not immediately available. It is produced by freeze-drying or spray-drying liquid or thawed plasma. It is shelf-stable for prolonged periods, can be stored at room temperature, and is easy to transport, reconstitute, and administer. It was widely used in WWII but fell out of favor due to the risk of infectious disease transmission. The German and French experiences with lyophilized plasma are the most extensive and show a good track record of efficacy and safety. Recent studies show many beneficial effects of dried plasma in the treatment of shock in large animal models. Currently, no FDA-licensed product is available in the USA, but several are under development.

Keywords

Lyophilized plasma Dried plasma Freeze-dried plasma Spray-dried plasma Battlefield transfusion Point-of-injury transfusion Prehospital transfusion 

Abbreviations

DCR

Damage control resuscitation

FDP

Freeze-dried plasma

FFP

Fresh frozen plasma

FLyP

French lyophilize plasma

LP

Lyophilized plasma

RBCs

Red blood cells

S/D

Solvent/detergent

SDP

Spray-dried plasma

TBI

Traumatic brain injury

TEG

Thrombelastography

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Mouayyad Zaza
    • 1
  • Kyle J. Kalkwarf
    • 1
  • John B. Holcomb
    • 1
  1. 1.Department of Surgery, Division of Acute Care SurgeryUniversity of Texas Health Science Center at Houston, Memorial Hermann HospitalHoustonUSA

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