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Cross-Roads to Drug Resistance and Metastasis in Breast Cancer: miRNAs Regulatory Function and Biomarker Capability

  • Nataly Naser Al Deen
  • Farah Nassar
  • Rihab NasrEmail author
  • Rabih TalhoukEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1152)

Abstract

Breast cancer and specifically metastatic breast cancer (mBC) constitutes a major health burden worldwide with the highest number of cancer-related mortality among women across the globe. Despite having similar subtypes, breast cancer patients present with a spectrum of aggressiveness and responsiveness to therapy due to cancer heterogeneity. Drug resistance and metastasis contribute to therapy failure and cancer recurrence. Research in the past two decades has focused on microRNAs (miRNAs), small endogenous non-coding RNAs, as active players in tumorigenesis, therapy resistance and metastasis and as novel non-invasive cancer biomarkers. This is due to their unique dysregulated signatures throughout tumor progression and their tumor suppressive/oncogenic roles. Identifying miRNAs signatures capable of predicting therapy response and metastatic onset in breast cancer patients might improve prognosis and offer prolonged median and relapse-free survival rate. Despite the growing reports on miRNAs as novel non-invasive biomarkers in breast cancer and as regulators of breast cancer drug resistance or metastasis, the quest on whether some miRNAs are capable of regulating both simultaneously is inevitable, yet understudied. This chapter will review the role of miRNAs as biomarkers and as active players in inducing/reversing anti-cancer drug resistance, driving/blocking metastasis or regulating both simultaneously in breast cancer.

Keywords

Breast cancer Metastatic breast cancer miRNA Drug resistance Metastasis Biomarker Prognostic Therapy-predictive Multi-drug resistance 

Abbreviations

BC

Breast cancer

CTCs

Circulating tumor cells

DCIS

Ductal carcinoma in situ

DFS

Disease-free survival

ER

Estrogen receptor

mBC

Metastatic breast cancer

MDR

Multidrug resistance

microRNAs

miRNAs or miRs

OS

Overall survival

PFS

Progression-free survival

TNBC

Triple negative breast cancer

Notes

Acknowledgments

The authors would like to acknowledge Prof. Mounir AbouHaidar, Professor of Virology at the University of Toronto Dept. Cell & Systems Biology, for his critical reading of the manuscript and Ms. Nancy Nasr Al Deen for illustrating Fig. 18.1. The authors would also like to acknowledge the support of the Lebanese National Council for Scientific Research (CNRS-L), the University Research Board (URB-AUB) and the International Breast Cancer and Nutrition (IBCN) project. Dr. Rabih Talhouk and Dr. Rihab Nasr are both members of IBCN. Ms. Nataly Naser Al Deen is the recipient of the AUB-CNRS-L scholarship.

Conflict of Interest

The authors declare no conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Biology, Faculty of Arts and SciencesAmerican University of BeirutBeirutLebanon
  2. 2.Department of Internal Medicine, Faculty of MedicineAmerican University of BeirutBeirutLebanon
  3. 3.Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of MedicineAmerican University of BeirutBeirutLebanon

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