Stem Cell Differentiation Directed by Material and Mechanical Cues

  • Caitlyn A. Moore
  • Alexandra Condé-Green
  • Pranela Rameshwar
  • Mark S. GranickEmail author


Stem cells play a crucial role in regenerative processes. They are heavily influenced by their microenvironment and, depending on the external signal, stem cells self-renew and differentiate toward specific lineages. It is critical to understand the diverse mechanical and material cues that induce stem cell behavior to harness these changes for tissue engineering applications. As such, significant advances have been made in regenerative approaches to breast reconstruction. In this review, we will discuss the role of extracellular signals in guiding stem cell differentiation and stress the role of material and mechanical cues that influence mammary adipose and epithelial tissues in the context of breast reconstruction.


Adipose stem cells Regenerative Tissue engineering Differentiation Materials 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Caitlyn A. Moore
    • 1
  • Alexandra Condé-Green
    • 1
  • Pranela Rameshwar
    • 1
  • Mark S. Granick
    • 1
    Email author
  1. 1.Division of Plastic Surgery, Department of General SurgeryRutgers New Jersey Medical SchoolNewarkUSA

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