Rodent Taxonomic and Biological Data

  • Hannsjörg SchröderEmail author
  • Natasha Moser
  • Stefan Huggenberger


Mice and rat represent the vast majority of animals used in biomedical and neuroscientific research. Although there are major differences of mainly quantitative character, the common bauplan of mammals allows their use as model organisms in basic research drug development even for the comparison with human beings. In this vein in particular transgenic mice with either deletion of defined genes or the insertion of, e.g., human disease-relevant genes, in the mouse genome play an extraordinary role. This chapter provides a short introduction into the taxonomic, breeding, and basic biological parameters that are relevant for the interpretation of physiological parameters comparing wild-type and transgenic mice.


Rodent mouse rat taxonomy biology Life history 


  1. Arndt S, Surjo D (2001) Methods for the behavioural phenotyping of mouse mutants. How to keep the overview. Behav Brain Res 125:39–42CrossRefGoogle Scholar
  2. Bab I, Hajbi-Yonissi C, Gabet Y, Müller R (2007) Microtomographic atlas of the mouse skeleton. Springer, New York. [C57BL/6 SJL, C3H]CrossRefGoogle Scholar
  3. Banbury Conference on Genetic Background in Mice (1997) Mutant mice and neuroscience: recommendations concerning genetic background. Neuron 19:755–759Google Scholar
  4. Boehm O, Zur Boch A et al (2007) Clinical chemistry reference database for Wistar rats and C57/BL6 mice. Biol Chem 388:547–554. [C57/BL6, rat]CrossRefGoogle Scholar
  5. Bowl MR, Dawson SJ (2015) The mouse as a model for age-related hearing loss- a mini-review. Gerontology 61:149–157CrossRefGoogle Scholar
  6. Hayakawa T, Iwaki T (2008) A color atlas of sectional anatomy of the rat. Adthree Publishing, Tokyo. [rat]Google Scholar
  7. Hof PR, Young WG, Bloom FE, Belichenko PV, Celio MR (2000) Comparative cytoarchitectonic atlas of the C57BL/6 and 129/Sv mouse brains. Elsevier, Amsterdam, pp 1–275. [C57BL/6 ,129/Sv]Google Scholar
  8. International Committee on Standardized Genetic Nomenclature for Mice. Rules and Guidelines for Nomenclature of Mouse and Rat Strains. Revised: October 2013.
  9. Iwaki T, Yamashita H, Hayakawa T (2001) A color atlas of sectional anatomy of the mouse. Adthree Publishing, Tokyo. [ddY, ICR]Google Scholar
  10. Köhler C, Ebert U et al (2005) Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels. Neurobiol Dis 20:528–540. [APP-SLxPS1mut mice]CrossRefGoogle Scholar
  11. Lee MJ, Chang CP et al (2009) Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus. PLoS One 4:e7868 [p23–e7868 [ST1. mouse created by N-ethyl-N-nitrosourea (ENU)-induced mutagenesis]Google Scholar
  12. Morcinek K, Köhler C et al (2013) Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent P301L tau transgenic pR5 mice. Brain Res 1497:73–84. [tau P301L mutant / pR5]CrossRefGoogle Scholar
  13. Müller WA, Frings S (2009) Tier- und Humanphysiologie: Eine Einführung. Springer-Verlag Berlin, HeidelbergGoogle Scholar
  14. Oshio K, Watanabe H et al (2005) Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel aquaporin-1. FASEB J 19:76–78. [AQP1-/-]CrossRefGoogle Scholar
  15. Paxinos G, Franklin KBJ (2012) Paxinos and Franklin’s the mouse brain in stereotaxic coordinates, 4th edn. Academic Press. [C57BL/6]Google Scholar
  16. Paxinos G, Watson C (2013) The rat brain in stereotaxic coordinates, 7th edn. Academic Press/Elsevier, Amsterdam. [Wistar]Google Scholar
  17. Prosen CA, Dore DJ et al (2003) The functional age of hearing loss in a mouse model of presbyacusis. I. Behavioral assessments. Hear Res 183:44–56. [C57BL/6]CrossRefGoogle Scholar
  18. Ruberte J, Carretero A, Navarro M (2017) Morphological mouse phenotyping. Academic Press/Elsevier, AmsterdamGoogle Scholar
  19. Schlesinger K, Mordkoff AM (1963) Locomotor activity and oxygen consumption. J Hered 54:177–182. [CS7BL/6J x DBA/2J]CrossRefGoogle Scholar
  20. Sharp PE, LaRegina MC (eds) (1998) The laboratory rat. CRC Press, Boca Raton. [rat]Google Scholar
  21. Suckow MA, Danneman P, Brayton C (2001) The laboratory mouse. CRC Press, Boca Raton, pp 1–168. [mouse]Google Scholar
  22. Treuting PM, Dintzis S, Liggitt D, Frevert CW (eds) (2012) Comparative anatomy and histology. A mouse and human atlas. Elsevier, Amsterdam. [C57BL/6]Google Scholar
  23. Wong JYF, Ross SA et al (2002) Proconvulsant-induced seizures in α4 nicotinic acetylcholine receptor subunit knockout mice. Neuropharmacology 43:55–64. [α4 nAChR knockout]CrossRefGoogle Scholar
  24. Zeisel A, Hochgerner H et al (2018) Molecular architecture of the mouse nervous system. Cell 174:999–1014. [mainly CD-1, Swiss]CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Hannsjörg Schröder
    • 1
    Email author
  • Natasha Moser
    • 1
  • Stefan Huggenberger
    • 2
  1. 1.Department II of AnatomyUniversity Hospital CologneCologneGermany
  2. 2.Institute of Anatomy and Clinical MorphologyUniversity of Witten/HerdeckeWittenGermany

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