Advertisement

Disorders of Hemostasis

  • Mala M. SanchezEmail author
  • Paul B. Cornia
Chapter

Abstract

Preoperative identification and management of hemostatic disorders minimizes bleeding complications from surgery. Taking a history is the most important part of assessing a patient’s perioperative bleeding risk, followed by lab testing if indicated. Management of specific disorders such as von Willebrand disease, hemophilia, and vitamin K deficiency in the perioperative period requires specific lab monitoring and product administration.

Keywords

Von Willebrand disease Hemophilia Vitamin K deficiency Coagulopathy Hemostatic disorders Bleeding disorders Disorders of hemostasis Preoperative Perioperative 

Notes

Acknowledgments

Robert E. Richard, MD, PhD

Director of Hematology, VA Puget Sound Health Care System

Associate Professor of Medicine, Division of Hematology, University of Washington

References

  1. 1.
    Rapaport SI. Preoperative hemostatic evaluation: which tests, if any? Blood. 1983;61(2):229–31. Open image in new windowGoogle Scholar
  2. 2.
    Chee YL, Crawford JC, Watson HG, et al. Guidelines on the assessment of bleeding risk prior to surgery or invasive procedures. British Committee for Standards in Haematology. Br J Haematol. 2008;140(5):496–504.CrossRefGoogle Scholar
  3. 3.
    Bonhomme F, Ajzenberg N, Schved JF, et al. Pre-interventional hemostatic assessment. Guidelines from the French Society of Anaesthesia and Intensive Care. Eur J Anaesthesiol. 2013;30:142–62.CrossRefGoogle Scholar
  4. 4.
    Weil IA, Seicean S, Neuhauser D, et al. Use and utility of hemostatic screening in adults undergoing elective, non-cardiac surgery. PLoS One. 2015;10(12):e0139139.CrossRefGoogle Scholar
  5. 5.
    Lind SE. The bleeding time does not predict surgical bleeding. Blood. 1991;77(12):2547–52.CrossRefGoogle Scholar
  6. 6.
    Jaffer IH, Reding MT, Key NS, et al. Hematologic problems in the surgical patient: bleeding and thrombosis. In: Hoffman R, Benz EJ, Silberstein LE, al e, editors. Hematology: basic principles and practice. 7th ed. Philadelphia: Elsevier; 2018. p. 2304.CrossRefGoogle Scholar
  7. 7.
    Kruse-Jarres R, Singleton TC, Leissinger CA. Identification and basic management of bleeding disorders in adults. J Am Board Fam Med. 2014;27(4):549–64.CrossRefGoogle Scholar
  8. 8.
    Castaman G, Linari S. Diagnosis and treatment of von Willebrand disease and rare bleeding disorders. J Clin Med. 2017;6(4):E45. Open image in new windowGoogle Scholar
  9. 9.
    Leebek FWG, Eikenboom JCJ. Von Willebrand’s disease. N Engl J Med. 2016;375:2067–80.CrossRefGoogle Scholar
  10. 10.
    Arya RC, Wander GS, Gupta P. Blood component therapy: which, when and how much. J Anaesthsiol Clin Pharmacol. 2011;27(2):2954–62.Google Scholar
  11. 11.
    American Society of Anesthesiologists Task Force on Perioperative Blood Management. Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on perioperative blood management. Anesthesiology. 2015;122(2):241–75. Open image in new windowGoogle Scholar
  12. 12.
    Szczepiorkowski ZM, Dunbar NM. Transfusion guidelines: when to transfuse. Hematology Am Soc Hematol Educ Program. 2013;2013:638–44.CrossRefGoogle Scholar
  13. 13.
    Srivastava A, Brewer AK, Mauser-Bunschoten EP, et al. Guidelines for the management of hemophilia. Hemophilia. 2013;19:e1–e47.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Medicine, Division of General Internal MedicineUniversity of WashingtonSeattleUSA
  2. 2.Department of MedicineUniversity of Washington and VA Puget Sound Health Care SystemSeattleUSA

Personalised recommendations