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Von Willebrand Disease

  • Thomas G. DeLougheryEmail author
Chapter

Abstract

This chapter discusses von Willebrand disease – the most common inherited bleeding disorder. It discusses the classification of the disease and diagnostic issues. Treatment by different subtypes and the use of desmopressin or the specific von Willebrand factor concentrates are also discussed.

Keywords

von Willebrand disease Multimers Humate-P GP Ib Desmopressin Factor VIII 

Suggested Reading

  1. Castaman G, Goodeve A, Eikenboom J. Principles of care for the diagnosis and treatment of von Willebrand disease. Haematologica. 2013;98(5):667–74.CrossRefGoogle Scholar
  2. Kruse-Jarres R, Johnsen JM. How i treat type 2B von Willebrand disease. Blood. 2018;131(12):1292–13.CrossRefGoogle Scholar
  3. Leebeek FWG, Susen S. Von Willebrand disease: clinical conundrums. Haemophilia. 2018;24(Suppl 6):37–43.CrossRefGoogle Scholar
  4. Ng CJ, Di Paola J. Von Willebrand disease: diagnostic strategies and treatment options. Pediatr Clin N Am. 2018;65(3):527–41.CrossRefGoogle Scholar
  5. Peyvandi F, Mamaev A, Wang JD, Stasyshyn O, Timofeeva M, Curry N, Cid AR, Yee TT, Kavakli K, Castaman G, Sytkowski A. Phase 3 study of recombinant von Willebrand factor in patients with severe von Willebrand disease who are undergoing elective surgery. J Thromb Haemost. 2019;17(1):52–62.CrossRefGoogle Scholar
  6. von Lillicrap D. Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy. Blood. 2013;122(23):3735–40.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Hematology/Medical Oncology, Department of Medicine, Pathology, and PediatricsOregon Health & Sciences UniversityPortlandUSA

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