Non-blood Product Agents for Bleeding Disorders

  • Thomas G. DeLougheryEmail author


This chapter discussed the use of desmopressin, tranexamic acid, epsilon-aminocaproic acids, estrogens, and rVIIa.


Desmopressin Tranexamic acid Epsilon-aminocaproic acids Congregated estrogen Trauma rVIIa 

Suggested Reading

  1. Desborough MJ, Oakland KA, Landoni G, Crivellari M, Doree C, Estcourt LJ, Stanworth SJ. Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials. J Thromb Haemost. 2017;15(2):263–72.CrossRefGoogle Scholar
  2. Franchini M. The use of desmopressin as a hemostatic agent: a concise review. Am J Hematol. 2007;82(8):731–5.CrossRefGoogle Scholar
  3. Goldstein M, Feldmann C, Wulf H, Wiesmann T. Tranexamic Acid Prophylaxis in Hip and Knee Joint Replacement. Dtsch Arztebl Int. 2017;114(48):824–30.PubMedPubMedCentralGoogle Scholar
  4. Ker K, Edwards P, Perel P, Shakur H, Roberts I. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ. 2012;344:e3054. Scholar
  5. Lamba G, Kaur H, Adapa S, Shah D, Malhotra BK, Rafiyath SM, Thakar K, Fernandez AC. Use of conjugated estrogens in life-threatening gastrointestinal bleeding in hemodialysis patients--a review. Clin Appl Thromb Hemost. 2013;19(3):334–7. Epub 2012 Mar 12.CrossRefPubMedGoogle Scholar
  6. Ramirez RJ, Spinella PC, Bochicchio GV. Tranexamic acid update in trauma. Crit Care Clin. 2017;33(1):85–99.CrossRefGoogle Scholar
  7. Schulman S. Pharmacologic tools to reduce bleeding in surgery. Hematol Am Soc Hematol Educ Program. 2012;2012:517–21.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Hematology/Medical Oncology, Department of Medicine, Pathology, and PediatricsOregon Health & Sciences UniversityPortlandUSA

Personalised recommendations