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Pharmaceutical Applications of Thermophilic Fungi

  • Gurram Shyam Prasad
Chapter

Abstract

Thermophilic fungi are the only group in eukaryotic microorganisms having the distinctive ability to grow at elevated temperatures and are of special interest due to their potential to synthesize a remarkable range of heat-stable secretary enzymes, viz. proteases, lipases, amylases, cellulases, xylanases, and cell-associated enzymes, viz. trehalase, invertase, and glycosidase. The majority of these enzymes have high-temperature stability and tolerance to a wide range of pH. Although thermophilic fungi form a diverse group of organisms and their incidence was reported from different substrates like mushroom compost, municipal waste, dung material, and coal mine soil, they remained unexplored compared to thermophilic eubacteria and archaebacteria. Though they are well known for wide biotechnological applications, their application in pharmaceutical industry is unexplored.

Hence, in this chapter, the potential pharmaceutical applications of thermophilic fungi are discussed.

Keywords

Extremophiles Biotransformation Drug-drug interactions Mammalian drug metabolism 

Notes

Acknowledgement

The author is thankful to Dr. G. Snithik, Dr. Akshaya Priya, and G. Preethi for extending their support in writing this review.

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Authors and Affiliations

  1. 1.Department of MicrobiologyVaagdevi Degree and Post Graduate CollegeWarangalIndia

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