Shaping Brain Rhythms: Dynamic and Control-Theoretic Perspectives on Periodic Brain Stimulation for Treatment of Neurological Disorders

  • John D. GriffithsEmail author
  • Jérémie R. Lefebvre
Part of the Springer Series in Cognitive and Neural Systems book series (SSCNS, volume 13)


Rhythmic, collective activity is a fundamental feature of neural systems. As a result of this, many of the challenges and opportunities involved in developing clinical tools from basic neuroscience knowledge come down to questions about control of dynamic, oscillatory networks. In this chapter we review a range of experimental and theoretical work on control of neural oscillations, in healthy brains and in relation to various clinical conditions. We highlight the main types of qualitative system behaviour that can result from application of periodic stimulation and present a simple case study on this using a mathematical model of rhythmogenesis in thalamocortical circuits. The concepts discussed here may, we hope, help provide some guidelines and principles for the development of future generations of more physiologically and dynamically informed brain stimulation techniques, paradigms, and researchers.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Krembil Centre for NeuroinformaticsCentre for Addiction and Mental HealthTorontoCanada
  2. 2.Department of PsychiatryUniversity of TorontoTorontoCanada
  3. 3.Krembil Research InstituteUniversity Health NetworkTorontoCanada
  4. 4.Department of MathematicsUniversity of TorontoTorontoCanada

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