Renal Aging and Chronic Kidney Disease in the Elderly: Which Are the Differences?

  • Carlos Guido Musso
  • Juan Florencio Macías-NúñezEmail author


Aging is a universal asynchronic and heterogeneous process which induces a series of changes in the organisms through time, characterized by the attenuation of functional performance compared to the maximal functional strength reached around the second decade of life. The glomerular filtration rate (GFR) reduction secondary to aging has a particular rate (1 ml/min per year since 40 years of age), but this is not necessarily the glomerular filtration declination rate in chronic nephropathy. A GFR reduction according to age, in a setting of normal creatininemia, uremia, hemoglobin, parathyroid hormone level, urinalysis, and kidney imaging, should be interpreted as normal renal aging instead of chronic kidney disease (CKD). However, it is worth mentioning that there is a minority of old individuals who have a relatively high GFR which can be interpreted as glomerular hyperfiltration due to early CKD (negative renal reserve) or to a successful renal aging (preserved renal reserve).


Aging Senescence Chronic kidney disease Senescent nephropathy 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Carlos Guido Musso
    • 1
    • 2
    • 3
  • Juan Florencio Macías-Núñez
    • 4
    Email author
  1. 1.Nephrology DivisionHospital Italiano de Buenos AiresBuenos AiresArgentina
  2. 2.Physiology DepartmentInstituto Universitario del Hospital Italiano de Buenos AiresBuenos AiresArgentina
  3. 3.Ageing Biology UnitHospital Italiano de Buenos AiresBuenos AiresArgentina
  4. 4.Departamento de MedicinaUniversity of SalamancaSalamancaSpain

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