Acute Reaction to Pentavalent Vaccine

  • Darko RichterEmail author

Practical Points

  • Anaphylaxis to vaccines is rare; approximately once in one million doses

  • Anaphylaxis usually occurs within the first 30 min after exposure, but sometimes it can take up to 4 h or longer

  • Symptoms of anaphylaxis are polymorphic, but well systematized and should be readily recognized and carefully appreciated

  • Anaphylaxis should be acutely treated with adrenaline, systemic corticosteroids, volume replacement, and antihistamines

  • Twenty-four-hour hospital observation is indicated because a biphasic course is possible in anaphylaxis

  • Diagnosis relies on skin testing with the culprit vaccine and its components, and where available, in vitro tests for the specific IgE to vaccine additives

  • Anaphylaxis contraindicates further immunization with the culprit vaccine; in exceptional vital situations, a desensitization-immunization graded dose protocol may be attempted in an intensive care setting


Diphtheria-tetanus-3-component acellular pertussis Inactivated polio Haemophilus influenzae type b Pentavalent vaccine 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Outpatient and Emergency Service, Department of PediatricsUniversity Hospital CenterZagrebCroatia

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