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Collapse and Angioedema at the Emergency Department

  • Iva Topalusic
  • Irena Ivkovic-Jurekovic
  • Martin Cuk
  • Marta Navratil
Chapter

Practical Points

  • Adverse drug reactions might rise as a result of reaction to the drug molecule or any of the excipients

  • Allergic reactions caused by corticosteroids have rarely been reported

  • Due to the possible contamination with cow’s milk proteins, lactose used as an excipient to drugs could be a iatrogenic cause of anaphylaxis in patients allergic to cow’s milk proteins

  • Patients allergic to cow’s milk proteins should be treated with lactose free preparations only

Keywords

Adverse drug reactions Methylprednisolone Drug provocation test 

References

  1. 1.
    Muraro A, Roberts G, Worm M, Bilo MB, Brockow K, Fernandez Rivas M, Santos AF, Zolkipli ZQ, Bellou A, Beyer K, Bindslev-Jensen C, Cardona V, Clark AT, Demoly P, Dubois AE, DunnGalvin A, Eigenmann P, Halken S, Harada L, Lack G, Jutel M, Niggemann B, Rueff F, Timmermans F, Vlieg-Boerstra BJ, Werfel T, Dhami S, Panesar S, Akdis CA, Sheikh A. Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology. Allergy. 2014;69(8):1026–45.CrossRefGoogle Scholar
  2. 2.
    Matura M, Goossens A. Contact allergy to corticosteroids. Allergy. 2000;55(8):698–704.CrossRefGoogle Scholar
  3. 3.
    Baeck M, Marot L, Nicolas JF, Pilette C, Tennstedt D, Goossens A. Allergic hypersensitivity to topical and systemic corticosteroids: a review. Allergy. 2009;64(7):978–94.CrossRefGoogle Scholar
  4. 4.
    Atanaskovic-Markovic M, Gavrovic-Jankulovic M, Jankovic S, Blagojevic G, Cirkovic-Velickovic T, Milojevic I, Simic D, Nestorovic B. Immediate allergic reaction to methylprednisolone with tolerance of other corticosteroids. Srp Arh Celok Lek. 2012;140(3–4):233–5.CrossRefGoogle Scholar
  5. 5.
    Aranda A, Mayorga C, Ariza A, Dona I, Blanca-Lopez N, Canto G, Blanca M, Torres MJ. IgE-mediated hypersensitivity reactions to methylprednisolone. Allergy. 2010;65(11):1376–80.CrossRefGoogle Scholar
  6. 6.
    Compalati E, Guerra L, Rogkakou A, Zanella C, Scordamaglia A, Passalacqua G. Angioedema after administration of methylprednisolone to treat drug allergy. Allergy. 2007;62(11):1346–8.CrossRefGoogle Scholar
  7. 7.
    Eda A, Sugai K, Shioya H, Fujitsuka A, Ito S, Iwata T, Funabiki T. Acute allergic reaction due to milk proteins contaminating lactose added to corticosteroid for injection. Allergol Int. 2009;58(1):137–9.CrossRefGoogle Scholar
  8. 8.
    Savvatianos S, Giavi S, Stefanaki E, Siragakis G, Manousakis E, Papadopoulos NG. Cow’s milk allergens as an infrequent cause of anaphylaxis to systemic corticosteroids. Clin Transl Allergy. 2011;1(Suppl 1):P18.CrossRefGoogle Scholar
  9. 9.
    Isaksson M, Bruze M. Allergic contact dermatitis in response to budesonide reactivated by inhalation of the allergen. J Am Acad Dermatol. 2002;46(6):880–5.CrossRefGoogle Scholar
  10. 10.
    Burgdorff T, Venemalm L, Vogt T, Landthaler M, Stolz W. IgE-mediated anaphylactic reaction induced by succinate ester of methylprednisolone. Ann Allergy Asthma Immunol. 2002;89(4):425–8.CrossRefGoogle Scholar
  11. 11.
    Pryse-Phillips WE, Chandra RK, Rose B. Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis. Neurology. 1984;34(8):1119–21.CrossRefGoogle Scholar
  12. 12.
    Rasanen L, Tarvainen K, Makinen-Kiljunen S. Urticaria to hydrocortisone. Allergy. 2001;56(4):352–3.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Iva Topalusic
    • 1
  • Irena Ivkovic-Jurekovic
    • 1
    • 2
  • Martin Cuk
    • 3
  • Marta Navratil
    • 1
    • 2
  1. 1.Children’s Hospital ZagrebZagrebCroatia
  2. 2.Faculty of MedicineUniversity of OsijekOsijekCroatia
  3. 3.Nephrology DepartmentChildren’s Hospital ZagrebZagrebCroatia

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