Bloody Streaks in Stool

  • Samin Sharafian

Practical Points

  • Food-protein induced enterocolitis syndrome (FPIES) is a disorder most commonly seen in infants between 1-3 weeks of age, with gross or microscopic hematochezia

  • The reaction is most common in exclusively breast fed infants as a result of cow’s milk or soy protein in mothers diet

  • Elimination of the responsible allergen leads to resolution of hematochezia within 72 h


Bloody stool Food-protein induced enterocolitis syndrome Oral food challenge Cow’s milk protein-induced proctocolitis 


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    Cherian S, Varshney P. Food protein-induced enterocolitis syndrome (FPIES): review of recent guidelines. Curr Allergy Asthma Rep. 2018;18(4):28.CrossRefGoogle Scholar
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    Leonard SA, Pecora V, Fiocchi AG, Nowak-Wegrzyn A. Food protein-induced enterocolitis syndrome: a review of the new guidelines. World Allergy Organ J. 2018;11(1):4.CrossRefGoogle Scholar
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    Greer FR, Sicherer SH, Burks AW, American Academy of Pediatrics Committee on Nutrition; American Academy of Pediatrics Section on Allergy and Immunology. Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics. 2008;121(1):183–91.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Samin Sharafian
    • 1
  1. 1.Department of Allergy and Clinical ImmunologyBushehr University of Medical Sciences, School of MedicineBushehrIran

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