The Gut-Brain Connection and Its Significance to Gastroenterologists

  • W. Harley Sobin


Some patients with more severe disorders of gut-brain interaction (DGBI) will fail to improve with gut-directed therapies and dietary change. Some of them will require use of central neuromodulators, and many will benefit from psychological therapies. The importance of a biopsychosocial model for functional gastrointestinal disorders is discussed. The significance of anxiety, depression, and early life trauma in determining the severity of functional GI disorders is reviewed. The incidence of psychiatric abnormalities in patients with IBS and other FGIDs is examined. The benefit of different psychological therapies for managing DBGIs is evaluated.


Disorders of gut-brain interaction (DGBI) Functional gastrointestinal disorders (FGID) Central neuromodulators Irritable bowel syndrome (IBS) Anxiety Depression Cognitive behavioral therapy (CBT) 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • W. Harley Sobin
    • 1
  1. 1.Pleasant PrairieUSA

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