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Boosting Macroevolution: Genomic Changes Triggering Qualitative Expansions of Regulatory Potential

  • Manuel Irimia
  • Ignacio Maeso
Chapter
Part of the Fascinating Life Sciences book series (FLS)

Abstract

Two main types of factors have been traditionally considered as potential driving forces underlying macroevolutionary patterns: environmental (“external”) cues and genetic and/or developmental (“internal”) factors. However, whereas the impact of non-gradual environmental changes has been extensively investigated, the contribution of internal causes, especially of genomic factors, has been approached in a less systematic manner, without clear definitions and classification schemes. Here, taking advantage of recent advances in comparative and functional genomics, we define three types of genomic changes that likely play important roles in macroevolutionary processes: (1) emergence of novel functional genomic properties, (2) large-scale genome reshaping and (3) qualitative single amplifications of regulatory potentials (which we term quasa-regs). Their unifying theme is their ability to qualitatively expand the genomic regulatory potential of the species. We review examples in which these types of changes have likely played important roles and discuss their potential macroevolutionary implications. We conclude that, although such changes may have a minor organismal impact at the time of emergence, they are likely to often have profound long-term effects by expanding regulatory abilities and opening new highways that boost the evolutionary process.

Notes

Acknowledgements

We would like to thank Alex de Mendoza, María Almuedo-Castillo, Rafael D. Acemel, Arnau Sebé-Pedrós and Isabel Almudí for insightful scientific discussions and critical comments on the manuscript. We are especially grateful to Alex de Mendoza for sharing unpublished data on the evolution of YY1 genes in animals. The authors are funded by the Spanish Ministerio de Economía y Competitividad (RYC-2016-20089 to I.M., BFU2014-55076-P and BFU2017-89201-P to M.I.) and by the European Research Council (ERC) under the European Union’s Seventh Framework Programme FP7 research and innovation programme (ERC-StG-LS2-637591 to M.I).

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Manuel Irimia
    • 1
    • 2
    • 3
  • Ignacio Maeso
    • 4
  1. 1.Centre for Genomic Regulation (CRG)Barcelona Institute of Science and Technology (BIST)BarcelonaSpain
  2. 2.Universitat Pompeu Fabra (UPF)BarcelonaSpain
  3. 3.Institució Catalana de Recerca i Estudis Avançats (ICREA)BarcelonaSpain
  4. 4.Centro Andaluz de Biología del Desarrollo (CABD)CSIC-Universidad Pablo de Olavide-Junta de AndalucíaSevilleSpain

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