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Analysis of miRNA Targets in Correlation to Neurodevelopment and Diagnosis of Autism Spectrum Disorder (ASD)

  • Emir Šehović
  • Lemana Spahić
  • Ajla Kulaglić
  • Lejla Smajlović-SkenderagićEmail author
  • Aida Hajdarpašić-Saračević
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 73)

Abstract

Autism Spectrum Disorder (ASD) is a broad spectrum of disorders which manifests itself through number of different phenotypes including those affecting communication and behavior. Our aim was to investigate small non coding RNA molecules, miRNAs, and their effect on target genes involved in neurodevelopment and ASD. In addition, we performed our study by investigating selected miRNAs as potential biomarkers for diagnosing children with ASD. MiRNAs selected for this study are found in saliva samples; therefore, sampling is non-invasive and very attractive diagnostic tool for ASD. Children diagnosed at an early stage of life would have the most benefit from an early intervention. We have identified 7 target genes of miRNAs suspected to be involved in ASD through an in silico analysis. We have found negative regulatory interactions between differentially expressed miRNAs and putative targets in ASD. The seven genes found through this study are all connected to neurodevelopmental functions and processes. Malfunction of some or all of these genes is found in connection to ASD and/or other neurodevelopmental disorders. The following 7 genes were found as best candidate genes of miRNAs studied: MAPK10, KCNMA1, DST, ZBTB20, GAS7, NTRK2 and SCN2A.

Keywords

Neurodevelopment miRNA Gene Autism spectrum disorder (ASD) 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Emir Šehović
    • 1
  • Lemana Spahić
    • 1
  • Ajla Kulaglić
    • 2
  • Lejla Smajlović-Skenderagić
    • 1
    Email author
  • Aida Hajdarpašić-Saračević
    • 2
  1. 1.International Burch University SarajevoIlidža, SarajevoBosnia and Herzegovina
  2. 2.Sarajevo School of Science and TechnologyIlidža, SarajevoBosnia and Herzegovina

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