Evaluation of Several Microalgal Extracts as Bioactive Metabolites as Potential Pharmaceutical Compounds
The nature derived therapeutics is getting intense attention rather than chemical synthesis and synthetic ones. Today the expansion of natural bioactive molecule market is started to be dominated and generic drug and therapeutic understanding looks like to leave its place to a new horizon. Thus, natural originated therapeutics under controlled production conditions are of importance. Besides the public attention on natural molecules are also gain advance and the demand on this bioactive molecules is also increasing dramatically. The bioactive molecules from microalgae show antioxidant, antibacterial, antiviral, anticancer, skin regenerative, sunscreen, antihypertensive, neuroprotective and immunostimulatory effects which are favorable for pharmaceutical, nutraceutical and cosmetics industry. Also a new concept known as functional nutrition also broaden the acceptability and utilization of microalgae derived bioactive metabolites in new dietary formulations. The expansion of microalgal biotechnology and the number of research gained from the role of biologically active microalgal metabolites display the emergence of the microalgae farming for new pharmaceutical formulations. In this study, we prepared solvent and water extracts of G. sulphuraria, N. texensis, S. bacillaris, E. carotinosa, C. minutissima, S. limacinum, C. cohnii, and C. vulgaris. Antioxidant activity using DPPH radical scavenging activity and total phenolic compounds were measured from the methanolic extracts and water extracts. With the bioactive extracts cytotoxicity test were performed on Hep-G2 and B16-F10 cell lines. The results display potential onset of novel therapeutic compounds derived from microalgae.
KeywordsMicroalgae Cyanobacteria Bioactivity Pharmaceutical Extraction
This study is a joint project with Ege University (Turkey), Liege University (Belgium), and Daegu Haany University (South Korea) named, KONNECT (Exploring the potential bioactive molecules from microalgae and understanding of their gene regulations-ALGACTIVE). The authors would like to thank The Scientific and Technological Council of Turkey (TÜBİTAK) for funding the project KONNECT 216M390. The authors declare that there is no conflict of interest.
- 1.Köse, A., Oncel, S.S.: Microalgal biotechnology ethics and intellectual property rights. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen Ve Mühendislik Dergisi 18(52), 116–127 (2016)Google Scholar
- 3.Oncel, S., Kose, A., Vardar, F., Torzillo, G.: From ancient tribes to modern societies, microalgae evolution from a simple food to an alternative fuel source. In: Kim, S.K. (ed.) Handbook of Marine Microalgae. Biotechnology Advances, pp. 127–144. Academic Press (2015)Google Scholar
- 8.de Morais, M.G., da Silva Vaz, B., de Morais, E.G., Costa, J.A.V.: Biologically active metabolites synthesized by microalgae corporation. BioMed Research International Volume Article ID 835761 (2015)Google Scholar
- 19.Pleissnera, D., Lim, W.C., Sun, Z., Lin, C.S.K.: Food waste as nutrient source in heterotrophic microalgae cultivation. Bioresour. Technol. 137, 139146 (2013)Google Scholar