Coated 3D Printed PLA Microneedles as Transdermal Drug Delivery Systems
Microneedles facilitate transdermal drug delivery by piercing microscale pores through the stratum corneum. They usually penetrate only thought the stratum corneum thus the nociceptors of the skin will not be stimulated. Therefore, as an alternative approach, microneedles provide a minimally invasive method for drug delivery. Additive manufacturing which is called threedimensional (3D) printing revolutionized the field of pharmaceutical and biomedical sciences due to their capabilities for fast and cost-effective prototyping of complex structures. Biodegradable 3D printed PLA microneedles are an emerging class of novel transdermal drug delivery systems. Aims of this study were to fabricate 3D printed microneedles and investigate for the first time the ability to coat different drug formulations on 3D printed microneedles. We demonstrated that 3D printing combined with the post-fabrication etching step could make ideally sized and shaped microneedles. Dip coating method revealed to be the best coating method for 3D printed microneedles because of its simplicity and ability to create a uniform load over the printed microneedles. We have also shown that 3D printed microneedles could successfully penetrate and break off into porcine skin.
Keywords3D printing PLA microneedles Transdermal drug delivery Coating
We would appreciate Assistant Professor Jasmina Hadžiabdić, Assistant Professor Ognjenka Rahić and Assistant Professor Alisa Elezović at the Department of Pharmaceutical Technology for helpful advices, and Teaching and Research Assistant Emina Aruković, DVM for preparation of porcine skin.
Conflict of Interest
Authors have no conflicts of interest to disclose.
- 3.Vranić, E., Tucak, A., Vrabac, Dž., Rahić, O., Elezović, A., Hadžiabdić, J.: Microneedle-assisted delivery of NSAIDs. In: Badnjevic, A. (eds.) CMBEBIH 2017. IFMBE Proceedings, vol. 62, pp. 311–316. Springer, Singapore (2017)Google Scholar
- 8.Yadav, D.J., Vaidya, K.A., Kulkarni, P.R., Raut, R.A.: Microneedles: promising technique for transdermal drug delivery. Int. J. Pharm. Bio Sci. 2(1), 684–708 (2010)Google Scholar
- 12.Haripriya, K., Chandra, K.S., Ajay, B.K.: Characterization of microchannels created by metal microneedles: formation and closure. J. List 13(3), 473–481 (2011)Google Scholar
- 15.Zhang, Y., Jiang, G., Hong, W., Gao, M., Xu, B., Zhu, J., et al.: Polymeric microneedles integrated with metformin-loaded and PDA/LA-coated hollow mesoporus SiO2 for NIR-triggered transdermal delivery on diabetic rats. ACS Appl. Bio Mater. (2018) (In press)Google Scholar
- 16.Donelly, R.F., McCrudden, M.T.C., Alkilani, A.Z., Larraneta, E., McAlister, E., Courtenay, A.J., et al.: Hydrogel-forming microneedles prepared from “super swelling” polymers combined with lyophilised wafers for transdermal drug delivery. PLoS One 9(10), 111–547 (2014)Google Scholar
- 22.Choi, Y., Lee, S.G., Jeong, J.H., Lee, K.M., Jeong, K.H., Yang, H., et al.: Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule. Int. J. Nanomed. 1, 289 (2013)Google Scholar
- 26.Ventola, C.L: Medical applications for 3D printing: current and projected uses. P&T 39(10), 704–711 (2014)Google Scholar
- 28.Jassim-Jaboori, A., Oyewumi, M.O.: 3D printing technology in pharmaceutical drug delivery: prospects and challenges. J. Biomol. Res. Ther. 04(4), 4 (2015)Google Scholar
- 32.Gidlof, Z.: Coating of bioceramic microneedles, Degree Thesis, Umeå University, Pharmacology and Clinical Neurosicience, Umeå (2017)Google Scholar