Maternal Use of Anticoagulants or Hemostatic Drugs and Infant Congenital Malformations

  • Bengt Källén


Coumarin derivatives have a known teratogenic effect but are relatively seldom used in early pregnancy nowadays. An association exists between maternal use of either anticoagulants or hemostatic drugs and a relatively severe malformation, notably a cardiovascular defect, in the offspring. This association is probably the result of a confounding by indication: a coagulopathy or a bleeding disorder.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Bengt Källén
    • 1
  1. 1.Tornblad Institute for Comparative EmbryologyLund UniversityLundSweden

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