Maternal Use of Cough or Common Cold Medicine and Infant Congenital Malformations

  • Bengt Källén


The greater part of the early literature on risks associated with cough medicines during pregnancy are case-control studies with a risk for various types of bias. The present prospective Swedish data give no reasons to expect any teratogenic effects, at least not from the drugs which have been used in Sweden during the past two decades. Data on components in traditional medicine are nearly totally lacking. Even though it is unlikely that they are teratogenic, it may be wise to avoid such drugs during pregnancy.


  1. Bártfai Z, Somoskövi A, Puhó EH, Czeizel AE. No teratogenic effect of prenoxdiazine: a population-based case-control study. Congenit Anom. 2007;47:16–21.CrossRefGoogle Scholar
  2. Bateman DN, McElhatton PR, Dickison D, Wren C, Matthews JN, O’Keefe M, Thomas SH. A case control study to examine the pharmacological factors underlying ventricular septal defects in the North of England. Eur J Clin Pharmacol. 2004;60:638–41.Google Scholar
  3. Choi JS, Han JY, Ahn HK, Ryu HM, Kim MY, Chung JH, Nava-Ocampo AA, Koren G. Fetal and neonatal outcomes in women reporting ingestion of licorice (Glycyrrhiza uralensis) during pregnancy. Planta Med. 2013;79:97–101.CrossRefGoogle Scholar
  4. Einarson A, Lyszkiewicz D, Koren G. The safety of dextromethorphan in pregnancy. Chest. 2001;119:466–9.CrossRefGoogle Scholar
  5. Gallo M, Sarkar M, Au W, Pietrzak K, Comas B, Smith M, Jaeger TV, Einarson A, Koren G. Pregnancy outcome following gestational exposure to Echinacea: a prospective controlled study. Arch Intern Med. 2000;160:3141–3.CrossRefGoogle Scholar
  6. Giveb JE, Loane M, Garne E, Nelen V, Barisic I, Randrianaivo H, Khoshnood B, Wiesel A, Rissman A, Lynch C, Neville AJ, Pierini A, Bekker M, Klungsoyr K, Latos Bielenska A, Cavero-Carbonell C, Addor MC, Zymak-Zakutnya N, Tucker D, Dolk H. Gastroschisis in Europe—a case-malformed-control study of medication and maternal illness during pregnancy as risk factors. Paediatr Perinat Epidemiol. 2017;31:549–59.CrossRefGoogle Scholar
  7. Heinonen OP, Slone D, Shapiro S. Birth defects and drugs in pregnancy. Littleton, MA: Publishing Sciences Group; 1977.Google Scholar
  8. Martínez-Frías M-L, Rodriguez-Pinilla E. Epidemiological analysis of prenatal exposure to cough medicines containing dextromethorphan: no evidence of human teratogenicity. Teratology. 2001;63:38–41.CrossRefGoogle Scholar
  9. Shaw GM, Todoroff K, Velie EM, Lammer EJ. Maternal illness, including fever and medication use as risk factors for neural tube defects. Teratology. 1998;57:1–7.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Bengt Källén
    • 1
  1. 1.Tornblad Institute for Comparative EmbryologyLund UniversityLundSweden

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