Maternal Use of Antacids or Drugs for Gastroesophageal Reflux Diagnosis (GERD) or Stomach Ulcer and Infant Congenital Malformations
Most previous studies indicate that the use of antacids or drugs for GERD carries no increased risk for infant congenital malformations. This has been verified in the present study with respect to antacids, H2-receptor antagonists, and proton pump inhibitors. Some questions remain concerning the use of sucralfate therapy where a weak teratogenic effect seems to exist. A specific association between use of sucralfate or alginic acid and infant esophageal atresia is suggested but has to be verified in independent studies. The absolute risk is, if existent, negligible.
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