Maternal Use of Antiviral Drugs, Immune Globulins, or Vaccines and Infant Congenital Malformations

  • Bengt Källén


There are very few signs of teratogenicity of antiviral drugs but further data are needed on specific drugs, notably on antiretroviral drugs. An observed association between use of zidovudine and infant hypospadias needs verification. Dolutegravir should if possible be avoided until the suspected association with neural tube defects has been clarified. Immune globulins can be used without risk during pregnancy. Vaccinations—notably based on living virus—should, if possible, be avoided during the first trimester but if inadvertent use occurs the risk of malformations is low.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Bengt Källén
    • 1
  1. 1.Tornblad Institute for Comparative EmbryologyLund UniversityLundSweden

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