Tryptophan-Stabilized Plasmonic Fe3O4/Ag Nanoparticles
It is obvious that the development of core–shell particles combining superparamagnetic core and plasmonic shell is attractive and opens a broad area of potential applications. In the current article, the “green” method for the preparation of stable Fe3O4 core Agshell nanoparticles (NPs) with the use of essential amino acid tryptophan is proposed. During Ag+ reduction of the surface of Fe3O4 NPs, tryptophan acts as a reducing and stabilizing agent. Consequently, the mixture of plasmonic NPs is formed, namely, small individual Ag NPs and complex core–shell Fe3O4 core Agshell composites having superparamagnetic core. Colloidal solutions exhibit absorption in the visible range of spectra near 420 nm that corresponds to localized surface plasmon resonance of silver. After the separation with magnetic field, Fe3O4 core Agshell NPs (the average size of 40–60 nm) have plasmon resonance band at max = 424 nm, indicating the formation of Ag shell on the magnetite surface. Obtained colloids were characterized by scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta-potential, and UV–Vis spectroscopy. According to the model in vitro test on skin fibroblast line BT5ta, more than 70% of cells were found to be viable relative to the control, during 24 h of incubation with NPs.
KeywordsNanoparticles Magnetite Ag nanoparticles Plasmonic nanostructures Core-shell nanoparticles Fe3O4/Ag
This work is supported in the framework of grants of the National Academy of Sciences of Ukraine for the research laboratory/group of young scientists of NASU for conducting investigations in priority directions of science and technology development in 2018 (no. 29/2018).
- 1.Sun CR, Du K, Fang C, Bhattarai N, Veiseh O, Kievit F, Stephen Z, Lee DH, Ellenbogen RG, Ratner B, Zhang MQ (2010) PEG-mediated synthesis of highly dispersive multifunctional superparamagnetic nanoparticles: their physicochemical properties and function in vivo. ACS Nano 4(4):2402–2410CrossRefGoogle Scholar
- 3.Pylypchuk IV, Kołodyńska D, Gorbyk P (2017) Gd (III) adsorption on the DTPA-functionalized chitosan/magnetite nanocomposites. Sep Sci Technol 53:1–11Google Scholar
- 6.Di Marco M, Sadun C, Port M, Guilbert I, Couvreur P, Dubernet C (2007) Physicochemical characterization of Ultrasmall Superparamagnetic Iron Oxide Particles (USPIO) for biomedical application as MRI contrast agents. Int J Nanomedicine 2(4):609Google Scholar
- 13.Iravani S, Korbekandi H, Mirmohammadi S, Zolfaghari B (2014) Synthesis of silver nanoparticles: chemical, physical and biological methods. Res Pharm Sci 9(6):385Google Scholar
- 23.Yu W, Huang Y, Pei L, Fan Y, Wang X, Lai K (2014) Magnetic Fe3 O4/Ag hybrid nanoparticles as surface-enhanced Raman scattering substrate for trace analysis of furazolidone in fish feeds. J Nanomater 2014:103Google Scholar
- 27.Shmarakov IO, Mukha IP, Karavan VV, Chunikhin OY, Marchenko MM, Smirnova NP, Eremenko AM (2014) Tryptophan-assisted synthesis reduces bimetallic gold/silver nanoparticle cytotoxicity and improves biological activity. Nano 1:6Google Scholar