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Environmental Stress: Mitochondria as Targets and Stressors in Cellular Metabolism

  • Jürgen Bereiter-HahnEmail author
  • Marina Jendrach
Chapter

Abstract

Stress is part of life of any organism: stresses may originate from biochemical processes within the cells as well as from impacts exerted by the environment among which disturbance of diurnal and seasonal rhythms, radiation effects, mental and physiological disturbances, and organ degeneration by reduced encroachment in confinement are those of particular significance in deep space exploration. The knowledge of mutual stress responses, their mechanisms and countermeasures will be a prerequisite for successful manned space missions. Mitochondria as the key players in the complex network of cellular functions are thus preferentially suited for cellular stress management.

Abbreviations

ATG

Autophagy-related genes

Drp1

Dynamin-related protein 1

ER/sER

Endoplasmic reticulum, smooth ER

HIF

Hypoxia inducible factor

Hsp

Heat shock protein

HUVEC

Human umbilical vein endothelial cells

I/R

Ischemia-reperfusion

IPC

Ischemic preconditioning

LACTB

Lactamase B

MAPK

Mitogen activated protein kinase

Mfn

Mitofusin

MOAS

Mitochondria on a string

Opa1

Optic atrophy protein

PASMC

Pulmonary arterial smooth muscle cells

PGC

Peroxisome proliferator-activated receptor γ (coactivator 1α and 1ß)

PHD

Prolylhydroxylase

PINK1

PTEN-induced putative kinase 1

SCN

Suprachiasmatic nuclei

Notes

Acknowledgments

This compilation is based on experiments which have been funded by the following organizations: DFG (grant BE423/23-2), BMBF Grant 0312826 and Gambro Dialysatoren GmbH, Hechingen. The EU (Integrated Project MiMage CT 2004-512020), the BMBF (NGFNplus NeuroNet Parkinson and GerontoMitosys 0315584A), and the Parkinson Initiative of the University Frankfurt Medical School. Vereinigung der Freunde und Förderer der Goethe Universität. During many years of research, material has been exchanged with many colleagues for Austria, Germany, United Kingdom, and United States.

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Institute for Cell Biology and NeurosciencesFrankfurt am MainGermany
  2. 2.Institut für NeuropathologieCharité—Universitätsmedizin BerlinBerlinGermany

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