Considerations for Development and Application of Health Monitoring Tools in Space

  • Ines KaufmannEmail author
  • Teodor Veres
  • Judith-Irina Buchheim
  • Alexander Choukér


Health maintenance and disease prevention in astronauts are of high priority during space missions. To achieve this aim, basic science of molecular biology has to be joined with modern noninvasive tools allowing high-fidelity research on diagnosing and monitoring of the astronauts’ health status. Experts from biology, medicine, and engineering should merge their expertise to enable additive effects for development and improvement of stress and immune-monitoring tools under extreme environmental conditions. This will hereby ensure not only the success of space missions, especially when leaving the Earth orbit in the future, but also will provide important impetus for many other applications on Earth as well.


  1. Andaloussi SE, Mager I, Breakefield XO, Wood MJ (2013) Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov 12:347–357CrossRefGoogle Scholar
  2. Antoniou M, Jorgensen AL, Kolamunnage-Dona R (2016) Biomarker-guided adaptive trial designs in phase II and phase III: a methodological review. PLoS One 11(2):e0149803CrossRefGoogle Scholar
  3. Ballantyne C (2007) Fact or fiction? Stress causes gray hair. Sci Am.
  4. Baumgartner C, Lewis GD, Netzer M, Pfeifer B, Gerszten RE (2010) A new data mining approach for profiling and categorizing kinetic patterns of metabolic biomarkers after myocardial injury. Bioinformatics 26(14):1745–1751CrossRefGoogle Scholar
  5. Brassard D, Clime L, Geissler M, Veres T (2015) Combining active pneumatic pumping and centrifugal forces : a new paradigm for the integration of bioanalytical assays. Proceedings of the 19th international conference on miniturized systems for chemistry and life sciences, MicroTAS, p 191Google Scholar
  6. Brassard D, Clime L, Mounier M, Veres T (2016) Programmable aliquots in passive microfluidic devices using a centrifugal platform with active pneumatic pumping. Proceedings of 20th international conference on miniaturized systems for chemistry and life sciences, MicroTAS, p 857Google Scholar
  7. Brassard D et al (2017) Advanced centrifugal microfluidic platform for the automation of clinical assays. American Association for Clinical Chemistry (AACC) annual meetingGoogle Scholar
  8. Brassard D et al (2018a) High-yield automated extraction of nucleic acids from whole blood using a centrifugal microfluidic platform with active pneumatic pumping. Proceedings of the 22th international conference on miniaturized systems for chemistry and life sciences, MicroTAS, p 141Google Scholar
  9. Brassard D et al (2018b) Microfluidic-based platform for universal sample preparation and biological assays automation for life-sciences research and remote medical applications. Deep space gateway science workshop (2018) LPI Contrib. No. 2063Google Scholar
  10. Clime L, Brassard D, Veres T (2014) Centrifugal microfluidic chip platform. PCT/IB2015/051591-US20170036208A1Google Scholar
  11. Clime L, Brassard D, Geissler M, Veres T (2015) Active pneumatic control of centrifugal microfluidic flows for lab-on-a-chip applications. Lab Chip 15:2400–2411CrossRefGoogle Scholar
  12. Cui F, Rhee M, Singh A, Tripathi A (2015) Microfluidic sample preparation for medical diagnostics. Annu Rev Biomed Eng 17:11.1–11.20CrossRefGoogle Scholar
  13. Erickson D, O'Dell L, Jiang L, Oncescu V, Gumus A, Lee S, Mancuso M, Mehta S (2014) Smartphone technology can be transformative to the deployment of lab-on-chip diagnostics. Lab Chip 14:3159–3167CrossRefGoogle Scholar
  14. Gidlow CJ, Randall J, Gillman J, Silk S, Jones MV (2016) Hair cortisol and self-reported stress in healthy, working adults. Psychoneuroendocrinology 63:163–169CrossRefGoogle Scholar
  15. Hurst VW, Peterson S, Garcia K, Ebert D, Ham D, Amponsah D, Dulchavsky S (2015) Concept of operations evaluation for using remote-guidance ultrasound for exploration spaceflight. Aerosp Med Hum Perform 86(12):1034–1038CrossRefGoogle Scholar
  16. Kirkpatrick AW, Blaivas M, Sargsyan AE, McBeth PB, Patel C, Xiao Z, Pian L, Panebianco N, Hamilton DR, Ball CG, Dulchavsky SA (2013) Enabling the mission through trans-atlantic remote mentored musculoskeletal ultrasound: case report of a portable hand-carried tele-ultrasound system for medical relief missions. Telemed J E Health 19(7):530–534CrossRefGoogle Scholar
  17. Kottnerus JA, van Weel C, Muris JWM (2002) Evaluation of diagnostic procedures. BMJ 324:477–480CrossRefGoogle Scholar
  18. Kraft NO, Lyons TJ, Binder H (2003) Intercultural crew issues in long-duration spaceflight. Aviat Space Environ Med 74:575–578PubMedGoogle Scholar
  19. Manzey D (2004) Human missions to Mars: new psychological challenges and research issues. Acta Astronaut 55:781–790CrossRefGoogle Scholar
  20. Mielczarek WS, Obaje EA, Bachmann TT, Kersaudy-Kerhoas M (2016) Microfluidic blood plasma separation for medical diagnostics: is it worth it? Lab Chip 16:3441–3448CrossRefGoogle Scholar
  21. Muzet A, Werner S, Fuchs G, Roth T, Saoud JB, Viola AU, Schaffhauser JY, Luthringer R (2016) Assessing sleep architecture and continuity measures through the analysis of heart rate and wrist movement recordings in healthy subjects: comparison with results based on polysomnography. Sleep Med 21:47–56CrossRefGoogle Scholar
  22. Nagrath S, Sequist L, Maheswaran S, Bell D, Irimia D, Ulkus L, Smith M, Kwak E, Digumarthy S, Muzikansky A, Ryan P, Balis U, Tompkins R, Haber D, Toner M (2007) Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450:1235–1239CrossRefGoogle Scholar
  23. Nicogossian AE, Pober DF, Roy SA (2001) Evolution of telemedicine in the space program and earth applications. Telemed J E Health 7(1):1–15CrossRefGoogle Scholar
  24. Otto C, Hamilton DR, Levine BD, Hare C, Sargsyan AE, Altshuler P, Dulchavsky SA (2009) Into thin air: extreme ultrasound on Mt Everest. Wilderness Environ Med 20(3):283–289CrossRefGoogle Scholar
  25. Otto C, Comtois JM, Sargsyan A, Dulchavsky A, Rubinfeld I, Dulchavsky S (2010) The Martian chronicles: remotely guided diagnosis and treatment in the Arctic Circle. Surg Endosc 24(9):2170–2177CrossRefGoogle Scholar
  26. Patabadige DEW, Jia S, Sibbitts J, Sadeghi J, Sellens K, Culbertson CT (2016) Micro total analysis systems: Fundamental advances and applications. Anal Chem 88:320–338CrossRefGoogle Scholar
  27. Ratajczak MZ, Ratajczak J (2016) Horizontal transfer of RNA and proteins between cells by extracellular microvesicles: 14 years later. Clin Transl Med 5:7CrossRefGoogle Scholar
  28. Sackmann EK, Fulton AL, Beebe DJ (2014) The present and future role of microfluidics in biomedical research. Nature 507:181–189CrossRefGoogle Scholar
  29. Stalder T, Steudte-Schmiedgen S, Alexander N, Klucken T, Vater A, Wichmann S, Kirschbaum C, Miller R (2017) Stress-related and basic determinants of hair cortisol in humans: A meta-analysis. Psychoneuroendocrinology 77:261–274CrossRefGoogle Scholar
  30. Tan SJ, Yobas L, Lee GY, Ong CN, Lim CT (2009) Microdevice for the isolation and enumeration of cancer cells from blood. Biomed Microdevices 11:883–892CrossRefGoogle Scholar
  31. Tkach M, Thery C (2016) Communication by extracellular vesicles: where we are and where we need to go. Cell 164:1226–1232CrossRefGoogle Scholar
  32. Turner ME, Pratkanis AR (1998) Twenty-five years of groupthink theory and research: lessons from the evaluation of a theory. Organ Behav Hum Decis Process 73:105–115CrossRefGoogle Scholar
  33. Ushakov IB, Karpov AA, Kryuchkov BI, Poliakov AV, Usov VM (2015) Promising options for medical robotics application in support of crew life activities and mitigation of medical risks during space flight. Aviakosm Ekolog Med 49(6):76–78PubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Ines Kaufmann
    • 1
    Email author
  • Teodor Veres
    • 2
    • 3
    • 4
  • Judith-Irina Buchheim
    • 5
  • Alexander Choukér
    • 5
  1. 1.Munich Clinic NeuperlachMunichGermany
  2. 2.Life Sciences DivisionNational Research Council of CanadaOttawaCanada
  3. 3.Biomedical Engineering DepartmentMcGill UniversityMontrealCanada
  4. 4.Bioengineering DepartmentMcGill UniversityMontrealCanada
  5. 5.Laboratory of Translational Research Stress and Immunity, Department of AnaesthesiologyHospital of the University of Munich (LMU)MunichGermany

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