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Selective Information Extraction Strategies for Cancer Pathology Reports with Convolutional Neural Networks

  • Hong-Jun YoonEmail author
  • John X. Qiu
  • J. Blair Christian
  • Jacob Hinkle
  • Folami Alamudun
  • Georgia Tourassi
Conference paper
Part of the Proceedings of the International Neural Networks Society book series (INNS, volume 1)

Abstract

To trust model predictions, it is important to ensure new data scored by the model comes from the same population used for model training. If the model is used to score new data different than the model’s training data, then predictions and model performance metrics cannot be trusted. Identifying and excluding these anomalous data points is an important task when using models in the real world. Traditional machine learning algorithms and classifiers don’t have the capability to abstain in this case. Here we propose a data-novelty detection algorithm for the Convolutional Neural Network classifier, yielding a rejection score for each new data point scored. It is a post-modeling procedure which examines the distribution of convolution filters to determine if the prediction should be trusted. We apply this algorithm to an information extraction model for a natural language text corpus. We evaluated the algorithm performance using a primary cancer site classification model applied to cancer pathology reports. Results demonstrate that the algorithm is an effective way to exclude cancer pathology reports from model scoring when they do not contain the expected information necessary to accurately classify the primary cancer type.

Keywords

Novelty detection Uncertainty determination Cancer pathology reports Information extraction Natural language processing Convolutional neural networks 

Notes

Acknowledgment

This work has been supported in part by the Joint Design of Advanced Computing Solutions for Cancer (JDACS4C) program established by the U.S. Department of Energy (DOE) and the National Cancer Institute (NCI) of the National Institutes of Health. This work was performed under the auspices of the U.S. Department of Energy by Argonne National Laboratory under Contract DE-AC02-06-CH11357, Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344, Los Alamos National Laboratory under Contract DE-AC5206NA25396, and Oak Ridge National Laboratory under Contract DE-AC05-00OR22725.

The authors wish to thank Valentina Petkov of the Surveillance Research Program from the National Cancer Institute and the SEER registry at Connecticut, Hawaii, Kentucky, New Mexico and Seattle for the pathology reports used in this investigation.

This research used resources of the Oak Ridge Leadership Computing Facility at the Oak Ridge National Laboratory, which is supported by the Office of Science of the U.S., Department of Energy under Contract No. DE-AC05-00OR22725.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Hong-Jun Yoon
    • 1
    Email author
  • John X. Qiu
    • 1
  • J. Blair Christian
    • 1
  • Jacob Hinkle
    • 1
  • Folami Alamudun
    • 1
  • Georgia Tourassi
    • 1
  1. 1.Biomedical Sciences, Engineering and Computing Group, Health Data Sciences InstituteOak Ridge National LaboratoryOak RidgeUSA

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