Breast Disease pp 209-219 | Cite as

Breast-Conserving Therapy: Hypofractionated and Conventional Whole-Breast Irradiation and Accelerated Partial-Breast Irradiation

  • Fusun Tokatlı
  • Maktav DincerEmail author


Breast irradiation after breast-conserving surgery (BCS) is an essential component of breast conservation therapy for maximizing local control and overall survival. The most widely used fractionation regimen until recently was 1.8- to 2-Gy daily fractions for a total of 45–50 Gy to the whole breast over 5 weeks with or without a boost to the surgical bed. However, a new optimal dose and fractionation schedule for radiation therapy after BCS has been defined recently. There is renewed interest in hypofractionation for whole-breast irradiation (WBI), and this approach has important practical advantages and biological implications. The convenience of this method may facilitate patient acceptance and compliance with radiation therapy. Irradiating only the tumor-bearing quadrant of the breast in one to ten fractions instead of irradiating the whole breast after BCS has also increased in popularity recently.


Irradiation Partial breast Breast conservation Accelerated radiotherapy Radiotherapy complications Cosmesis Boost dose Randomized trials Breast conserving Canadian trial Cosmetic outcome Fraction size Hypofractionation Normal tissue Local control Meta-analyses START-A START-B UK FAST Survival Whole breast α/β ratio 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Radiation Oncology, Medicana International HospitalIstanbulTurkey
  2. 2.Department of Radiation OncologyFlorence Nightingale HospitalIstanbulTurkey

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