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Micro-Computed Tomography (Micro-CT) Analysis as a New Approach for Characterization of Drug Delivery Systems

  • Müge Kılıçarslan
  • Miray Ilhan
  • Kaan Orhan
Chapter

Abstract

In this chapter, examples from the limited number of studies conducted on the use of micro-CT analysis method, which has been previously used in various areas, for the in vitro and/or in vivo characterization of drug delivery systems are presented, and the possibility of using micro-CT on characterization of drug delivery systems (granule, tablet, dome matrix, micro- and nanoparticle, scaffold, film, implant, in situ implant, etc.) is evaluated. In addition, some of the in vitro micro-CT analysis data on different types of drug delivery systems (complex film and nanoparticle) prepared by our study group is presented, and the future advantages and disadvantages of micro-CT analyses used in the evaluation of drug formulations are discussed within the scope of these experiences. Based on the results of our study, it is found that the ability to perform several quantitative analyses such as size and volume analysis rather than just three-dimensional imaging may provide ease of use by working with a simple method instead of multiple methods during the development phase of the formulation and may guide the study on a sounder basis despite the disadvantages of the method such as the resolution of the device, duration of the analysis period, and high cost.

Keywords

Micro-CT Drug delivery Microsphere Nanoparticle Scaffold Tablet Matrix system Implant 

Notes

Acknowledgments

This research has been supported by Ankara University Scientific Research Projects Coordination Unit (grant number, 17A0234001; continued; grant number, 17H0237006, 2017).

Supplementary material

Movie Picture 13.1

3D Micro-CT movie of PEC film (F1) (AVI 3515989 kb)

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Müge Kılıçarslan
    • 1
  • Miray Ilhan
    • 1
  • Kaan Orhan
    • 2
    • 3
    • 4
  1. 1.Faculty of Pharmacy, Department of Pharmaceutical TechnologyAnkara UniversityAnkaraTurkey
  2. 2.Faculty of Dentistry, Department of Dentomaxillofacial RadiologyAnkara UniversityAnkaraTurkey
  3. 3.Faculty of Medicine, OMFS IMPATH Research Group, Department of Imaging and PathologyUniversity of LeuvenLeuvenBelgium
  4. 4.Oral and Maxillofacial Surgery, University Hospitals LeuvenUniversity of LeuvenLeuvenBelgium

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