Advertisement

Parotid Gland Tumors

  • José Aurillo Rocha
  • Ramon Andrade De MelloEmail author
Chapter

Abstract

The parotid glands are the largest salivary glands in humans and are frequently involved in disease processes. Approximately 25% of parotid masses are nonneoplastic; the remaining 75% are neoplastic. Anatomically, the parotid gland is the most frequent site of salivary gland tumors, accounting for approximately 80–85% of these tumors. Approximately three-fourths of parotid lesions are benign, and approximately 25% are malignant.

Keywords

Parotid Gland Tumors Chemotherapy Radiotherapy 

References

  1. 1.
    Eneroth CM, Franzen S, Zajicek J (1967) Aspiration biopsy of salivary gland tumors. A critical review of 910 biopsies. Acta Cytol 11(6):470–472. [Medline]PubMedGoogle Scholar
  2. 2.
    Rice DH, Becker T (1987) Magnetic resonance imaging of the salivary glands. A comparison with computed tomographic scanning. Arch Otolaryngol Head Neck Surg 113(1):78–80. [Medline]CrossRefGoogle Scholar
  3. 3.
    Stafford ND, Wilde A (1997) Parotid cancer. Surg Oncol 6(4):209–213. [Medline]CrossRefGoogle Scholar
  4. 4.
    Laforga JB (1999) Mucoepidermoid carcinoma of the parotid gland [letter]. Acta Cytol 43(3):515–517. [Medline]PubMedGoogle Scholar
  5. 5.
    Pinkston JA, Cole P (1999) Incidence rates of salivary gland tumors: results from a population-based study. Otolaryngol Head Neck Surg 120(6):834–840. [Medline]CrossRefGoogle Scholar
  6. 6.
    Suzuki M, Ichimiya I, Matsushita F et al (1998) Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland. J Laryngol Otol 112(10):944–947. [Medline]CrossRefGoogle Scholar
  7. 7.
    Ozcan C, Talas D, Gorur K (2007) Parotid gland mucoepidermoid carcinoma associated with myasthenia gravis. J Craniofac Surg 18(5):1055–1058. [Medline]CrossRefGoogle Scholar
  8. 8.
    Zhan KY, Lentsch EJ (2016) Basal cell adenocarcinoma of the major salivary glands: a population-level study of 509 cases. Laryngoscope 126(5):1086–1090. [Medline]CrossRefGoogle Scholar
  9. 9.
    Shikhani A, Samara M, Allam C et al (1987) Primary lymphoma in the salivary glands: report of five cases and review of the literature. Laryngoscope 97(12):1438–1442. [Medline]CrossRefGoogle Scholar
  10. 10.
    Alba Garcia JR, Armengot Carceller M, Zapater Latorre E et al (2008) Malignant fibrohistiocytoma of the parotid region. Report of a case. Med Oral Patol Oral Cir Bucal 13(2):E148–E150. [Medline]PubMedGoogle Scholar
  11. 11.
    Johns ME (1980) Parotid cancer: a rational basis for treatment. Head Neck Surg 3(2):132–141. [Medline]CrossRefGoogle Scholar
  12. 12.
    Domenick NA, Johnson JT (2011) Parotid tumor size predicts proximity to the facial nerve. Laryngoscope 121(11):2366–2370. [Medline]CrossRefGoogle Scholar
  13. 13.
    Luna Ortiz K, Rascon Ortiz M, Sanson Riofrio JA et al (2007) Control of Frey’s syndrome in patients treated with botulinum toxin type A. Med Oral Patol Oral Cir Bucal 12(1):E79–E84. [Medline]PubMedGoogle Scholar
  14. 14.
    Takushima A, Harii K, Asato H et al (2004) Neurovascular free-muscle transfer for the treatment of established facial paralysis following ablative surgery in the parotid region. Plast Reconstr Surg 113(6):1563–1572. [Medline]CrossRefGoogle Scholar
  15. 15.
    Shang J, Shui Y, Sheng L et al (2008) Epidermal growth factor receptor and human epidermal growth receptor 2 expression in parotid mucoepidermoid carcinoma: possible implications for targeted therapy. Oncol Rep 19(2):435–440. [Medline]PubMedGoogle Scholar
  16. 16.
    Frankenthaler RA, Luna MA, Lee SS et al (1991) Prognostic variables in parotid gland cancer. Arch Otolaryngol Head Neck Surg 117(11):1251–1256. [Medline]CrossRefGoogle Scholar
  17. 17.
    O'Brien CJ, Soong SJ, Herrera GA et al (1986) Malignant salivary tumors – analysis of prognostic factors and survival. Head Neck Surg 9(2):82–92. [Medline]CrossRefGoogle Scholar
  18. 18.
    Schwentner I, Obrist P, Thumfart W et al (2006) Distant metastasis of parotid gland tumors. Acta Otolaryngol 126(4):340–345. [Medline]CrossRefGoogle Scholar
  19. 19.
    Tumours of the salivary glands. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) Pathology and genetics of head and neck tumours. World Health Organization, Lyon, 2005, p 209Google Scholar
  20. 20.
    Mamlouk MD, Rosbe KW, Glastonbury CM (2015) Paediatric parotid neoplasms: a 10 year retrospective imaging and pathology review of these rare tumours. Clin Radiol 70(3):270–277. [Medline]CrossRefGoogle Scholar
  21. 21.
    Illes RW, Brian MB (1986) A review of the tumors of the salivary gland. Surg Gynecol Obstet 163(4):399–404. [Medline]PubMedGoogle Scholar
  22. 22.
    Skolnik EM, Friedman M, Becker S et al (1977) Tumors of the major salivary glands. Laryngoscope 87(6):843–861. [Medline]CrossRefGoogle Scholar
  23. 23.
    Snyderman NL, Johnson JT (1987) Salivary gland tumors. Diagnostic characteristics of the common types. Postgrad Med 82(5):105–108, 110–112. [Medline]CrossRefGoogle Scholar
  24. 24.
    Spiro RH (1986) Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 8(3):177–184. [Medline]CrossRefGoogle Scholar
  25. 25.
    Guzzo M, Locati LD, Prott FJ et al (2010) Major and minor salivary gland tumors. Crit Rev Oncol Hematol 74:134CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • José Aurillo Rocha
    • 1
  • Ramon Andrade De Mello
    • 2
    • 3
    Email author
  1. 1.Oncology & Hematology Nucleus of Ceará (NOHC)São Mateus HospitalFortalezaBrazil
  2. 2.Division of Medical OncologyFederal University of São Paulo (UNIFESP) & Hospital Israelita Albert EinsteinSão PauloBrazil
  3. 3.Department of Biomedical Sciences and MedicineUniversity of AlgarveFaroPortugal

Personalised recommendations