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Squamous Cell Carcinoma of the Head and Neck

  • Emmanuel Seront
  • Jean-Pascal MachielsEmail author
  • Sandra Schmitz
Chapter

Abstract

Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common cancer worldwide. The main risk factors for cancers of the oral cavity, larynx, oropharynx, and hypopharynx are alcohol and tobacco abuse. In addition, the human papillomavirus is another established cause of oropharyngeal cancer. The treatment for early-stage squamous cell cancers of the head and neck includes generally only one treatment modality, either surgery or radiotherapy. The treatment for locally advanced head and neck cancers is multimodal, with either definitive chemoradiation or surgery followed by adjuvant radiation or chemoradiation as indicated by pathologic features. However, despite this aggressive multimodal treatment, 40–60% of the patients will relapse, highlighting the importance to improve our initial local control. For recurrent and/or metastatic disease, systemic agent is indicated, including chemotherapy, biological agents and immune checkpoint inhibitors. This chapter describes the molecular pathogenic pathways implicated in HNSCC development as well as its general management.

Keywords

Head and neck cancer Radiotherapy Cetuximab Immune checkpoint inhibitors Human papilloma virus 

Abbreviations

CRT

Chemoradiotherapy

CT

Computed Tomography

DW-MRI

Diffusionweighted MR

HNC

Head and Neck Cancer

HNSCC

Head and Neck Squamous Cell Carcinoma

HPV

Human Papilloma Virus

IHC

Immunohistochemistry

IMRT

Intensity Modulated Radiotherapy

LA-HNSCCC

Locally advanced Head and neck Squamous cell carcinoma

LRC

Locoregional control

MRI

Magnetic Resonance Imaging

ND

Neck Dissection

ORR

Overall response rate

OS

Overall Survival

PET

Positron Emission Tomography

PFS

Progression Free Survival

RT

Radiotherapy

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Emmanuel Seront
    • 1
    • 2
  • Jean-Pascal Machiels
    • 1
    Email author
  • Sandra Schmitz
    • 1
  1. 1.Department of Medical Oncology and Head and Neck surgery, Institut Roi Albert II, Cliniques universitaires Saint-Luc and Institut de Recherche Clinique et ExpérimentaleUniversité catholique de LouvainBrusselsBelgium
  2. 2.Department of Medical OncologyHôpital de JolimontHaine-Saint-PaulBelgium

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