• Richard Hill


Our DNA is continuously assaulted from a plethora of sides including exogenous environmental sources (for examples ionizing radiation (IR) or exposure to environmental genotoxic compounds) and endogenous sources such as replication fork collapse during regular DNA replication, during normal DNA repair events and immunoglobulin V(D)J gene rearrangement. However the incorrect repair of DNA breaks results in significant genomic instability due to gross chromosomal loss, amplification, or rearrangements that can lead to cancer.


Apoptosis Cell cycle Cell death 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Richard Hill
    • 1
  1. 1.Brain Tumour Research CentreInstitute of Biomedical and Biomolecular Sciences, IBBS, University of PortsmouthPortsmouthUK

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