Small Intestine Cancer

  • Pedro Nazareth AguiarJr.
  • Carmelia Maria Noia Barreto
  • Nora Manoukian Forones
  • Hakaru Tadokoro
  • Ramon Andrade De MelloEmail author


Primary small intestine cancers are not frequent, accounting for <1% of all adult neoplasms. Various histologic types are associated with small intestine cancer. The most common used to be adenocarcinoma; however, carcinoid tumors are showing an improved incidence and are the most common histologic type in some series. Adenocarcinomas are more frequent in the duodenum, while carcinoid tumors are more common in the ileum. Other histologic types are lymphomas and sarcomas. The symptoms are vague and non-specific. Less of an index of suspicious can cause a late the diagnosis. The stage at diagnosis is the most important prognostic factor. Radiologic and endoscopic exams can be performed to achieve a specimen sample and to stage the disease. Early tumors can be treated properly with surgical resection. Adjuvant treatment for adenocarcinoma has not been studied in large trials, but it is indicated in extrapolating colon data. The treatment for advanced adenocarcinoma of the small intestine has only been studied in a few large cohorts. Treatment for other histologic types is discussed in a separated chapter.


Small intestine Cancer Chemotherapy 





Upper Endoscopy


Video Capsule Endoscopy


Computed Tomography


Positron Emission Tomography


American Joint Committee on Cancer


American Society of Clinical Oncology


Fluouracil plus Oxaliplatin


Fluouracil plus Irinotecan


Programmed-Death Receptor 1


Food and Drug Administration


European Society of Medical Oncology


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Pedro Nazareth AguiarJr.
    • 1
  • Carmelia Maria Noia Barreto
    • 2
  • Nora Manoukian Forones
    • 3
  • Hakaru Tadokoro
    • 4
  • Ramon Andrade De Mello
    • 5
    • 6
    Email author
  1. 1.Faculdade de Medicina do ABCSanto AndréBrazil
  2. 2.Instituto Avanços em MedicinaSão PauloBrazil
  3. 3.Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP)São PauloBrazil
  4. 4.Division of Medical Oncology, Escola Paulista de MedicinaFederal University of São PauloSão PauloBrazil
  5. 5.Division of Medical OncologyFederal University of São Paulo (UNIFESP) & Hospital Israelita Albert EinsteinSão PauloBrazil
  6. 6.Department of Biomedical Sciences and MedicineUniversity of AlgarveFaroPortugal

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