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Breast Cancer

  • Inês Monteiro
  • Teresa Alvarez
  • Jean-Yves Meuwly
  • Khalil Zaman
Chapter

Abstract

Breast cancer is not a single disease. It is highly heterogeneous in its molecular biology and natural evolution, impacting treatment response and prognosis. It is one of the most prevalent cancers worldwide with high impact on individual, social and economic levels. Nowadays, breast cancer treatment demands a multidisciplinary approach and the involvement of informed patients. Personalized breast cancer care should mean both considering the prognostic and predictive biomarkers of a single tumor and considering an individual patient’s preferences.

Keywords

Breast cancer Biomarkers Targeted therapy 

Abbreviations

AI

Aromatase inhibitor

BC

breast cancer

CDK4/6

cyclin-dependent kinases 4/6

cD1

cyclin D1

CT

computed tomography

ER

estrogen receptor

ET

endocrine therapy

GnRH

gonadotropin-releasing hormone

HER2

human epidermal growth factor receptor 2

LN

lymph node

mAb

monoclonal antibody

MBC

metastatic breast cancer

MRI

magnetic resonance imaging

NST

no special type

OFS

ovarian function suppression

OS

overall survival

PARP

poly-adenosine diphosphate-ribose polymerase inhibitor

pCR

pathological complete response

PET-CT

positron emission computed tomography

PFS

progression-free survival

PR

progesterone receptor

SERD

selective estrogen receptor degrader

SERM

selective estrogen receptor modulator

SLN

sentinel lymph node

SLNB

sentinel lymph node biopsy

TILs

tumor-infiltrating lymphocytes

TNM

tumor node metastasis

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Inês Monteiro
    • 1
  • Teresa Alvarez
    • 1
  • Jean-Yves Meuwly
    • 2
  • Khalil Zaman
    • 3
  1. 1.Institute of PathologyUniversity Hospital of Lausanne (CHUV)LausanneSwitzerland
  2. 2.Department of Diagnostic and Interventional RadiologyUniversity Hospital of Lausanne (CHUV) and University of Lausanne (UNIL)LausanneSwitzerland
  3. 3.Breast Center, Medical Oncology, Department of OncologyUniversity Hospital CHUVLausanneSwitzerland

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