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ACNet: Aggregated Channels Network for Automated Mitosis Detection

  • Kaili Cheng
  • Jiarui Sun
  • Xuesong Chen
  • Yanbo Ma
  • Mengjie Bai
  • Yong ZhaoEmail author
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11439)

Abstract

Mitosis count is a critical predictor for invasive breast cancer grading using the Nottingham grading system. Nowadays mitotic count is mainly performed on high-power fields by pathologists manually under a microscope which is a highly tedious, time-consuming and subjective task. Therefore, it is necessary to develop automated mitosis detection methods that can save a large amount of time for pathologists and enhance the reliability of pathological examination. This paper proposes a powerful and effective novel framework named ACNet to count mitosis by aggregating auxiliary handcrafted features associated with tissue texture into CNN and jointly training neural network in an end-to-end way. Completed Local Binary Patterns (CLBP) features, Scale Invariant Feature Transform (SIFT) features and edge features are extracted and used in the classification task. In the process of network training, we expand the original training set by utilizing hard example mining, making our network focus on classification of the most difficult cases. We evaluate our ACNet by conducting experiments on the public MITOSIS dataset from MICCAI TUPAC 2016 competition and obtain state-of-the-art results.

Keywords

Mitosis detection Breast histopathology CLBP SIFT Edge 

Notes

Acknowledgments

This work was supported by Science and Technology Planning Project of Shenzhen (No. NJYJ20170306091531561), Science and Technology Planning Project of Shenzhen (No. JCYJ20160506172651253), and National Science and Technology Support Plan, China (No. 2015BAK01B04).

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Kaili Cheng
    • 1
  • Jiarui Sun
    • 1
  • Xuesong Chen
    • 1
  • Yanbo Ma
    • 1
  • Mengjie Bai
    • 1
  • Yong Zhao
    • 1
    Email author
  1. 1.School of Electronic and Computer EngineeringPeking University Shenzhen Graduate SchoolShenzhenChina

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