Phylogeny of Neem and Related Species in the Meliaceae Family

  • Nagesh A. Kuravadi
  • Malali GowdaEmail author
Part of the Compendium of Plant Genomes book series (CPG)


Neem belongs to Meleaceae family also called Mahogany family. It includes 50 genera and 1400 species. In India, it is represented by 20 genera and 70 species. However, the chemical composition of these species has high variability. This study was aimed at understanding the genetic distance of neem tree in relation to other family members (Azadirachta indica, Amoora lawii, Dysoxylum malabaricum, Khaaya, Melia Azadirachta, Melia dubia, Swietenia macrophylla, Sweitenia mahogany, Soymida fabrifuga, Toona ciliate, Walsuria trifoliate). Additionally, species were also analysed for Azadirachtin concentration in the leaf with the aim to find clues about the evolution of Azadirachtin pathway and the family members who share it. Neem tree synthesises a large number of unique bioactive compounds. Chemical synthesis of many of these compounds has been tried in the laboratory; complex synthesis process and molecular complexity involved makes the process not a viable option for commercial production (Veitch et al. 2008). However, to increase the natural production or engineering new production methods require a deeper understanding of the synthesis process and also the genes/enzymes involved in their biosynthesis. Sequencing of neem genome is aimed at elucidating all the genes that are present in neem and understanding pathways of synthesis for many of the compounds that are produced by neem tree. Studying neem genome will also be useful in understanding the mechanism of resistance to abiotic stress.


Phylogeny Meleaceae rbcL gene PCR Limonide biosynthetic pathway 



We acknowledge Genomics facility (BT/PR3481/INF/22/140/2011) at Centre for Cellular and Molecular Platforms, Bangalore for sequencing of Neem genomes. We acknowledge Pradeep H, Aarati Karaba, Manojkumar S and Annapurna for their help in NGS library preparation and sequencing. We thank Ashmita G and Divya S for their help in manual curation of SSR markers. We are grateful to Rajanna, National Botanical Garden, University of Agricultural Sciences, GKVK campus, Bangalore for his help during neem sample collection.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Centre for Cellular and Molecular Platforms, National Centre for Biological SciencesBengaluruIndia
  2. 2.Center for Functional Genomics and Bio-Informatics, the University of TransDisciplinary and Health SciencesBengaluruIndia

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