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Brain Monitoring

  • Cesar Reis
  • Onat Akyol
  • Wing Man Ho
  • Richard ApplegateII
  • Gary Stier
  • Robert Martin
  • John Zhang
Chapter
Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Abstract

In experimental neurologic injury models, evaluating the effect of any manipulation or treatment on cerebral blood flow (CBF) gives significant information about metabolic changes in rodent’s brains. There are different methods of investigating brain microcirculation based on changes of H2 clearance, radionuclide labeled microspheres, pial artery diameter, and iodoantipyrine. Another method, CBF measurement using laser Doppler, is based on measurements of absolute changes in regional blood flow of the cortex and detects real time changes in microvascular perfusion in a noninvasive manner. In this chapter we will approach the brain monitoring mechanism with laser Doppler equipment in a step-by-step fashion. We will demonstrate the potential pitfalls and how to avoid them. A rat model will be used to demonstrate brain monitoring and the associated procedures that accompany the process.

Keywords

Brain monitoring Syncope Animal models Brain imaging Cerebral blood flow 

Notes

Acknowledgments

A special thank you to Devin McBride for helping set up the equipment for the CBF pictures.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Cesar Reis
    • 1
    • 2
  • Onat Akyol
    • 2
  • Wing Man Ho
    • 2
  • Richard ApplegateII
    • 3
    • 4
  • Gary Stier
    • 1
  • Robert Martin
    • 1
  • John Zhang
    • 1
    • 2
    • 5
    • 6
  1. 1.Department of AnesthesiologyLoma Linda University Medical CenterLoma LindaUSA
  2. 2.Department of Physiology and PharmacologyLoma Linda University School of MedicineLoma LindaUSA
  3. 3.Department of AnesthesiologyUC Davis School of MedicineSacramentoUSA
  4. 4.Department of Pain MedicineUC Davis School of MedicineSacramentoUSA
  5. 5.Department of AnesthesiologyLoma Linda University School of MedicineLoma LindaUSA
  6. 6.Department of NeurosurgeryLoma Linda University School of MedicineLoma LindaUSA

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