The Non-human Primate Model of Cerebral Vasospasm

  • R. Loch Macdonald
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


Cerebral vasospasm classically refers to narrowing of the large subarachnoid cerebral arteries occurring 3–14 days after blood clots are deposited in the subarachnoid space after subarachnoid hemorrhage (SAH) from any cause. It is most common after aneurysmal SAH because this process deposits the most dense and voluminous blood in the subarachnoid space and it is this blood clot that causes vasospasm. It is recommended that cerebral vasospasm be called angiographic vasospasm and to use this term to refer to the angiographic appearance of the cerebral arteries. The clinical consequences of angiographic vasospasm should be referred to as delayed cerebral ischemia (DCI). DCI is an important cause of morbidity and mortality after SAH and is usually associated with severe angiographic vasospasm. Animal models of angiographic vasospasm have been developed because of the difficulties modeling delayed vasospasm in vitro. These models use one of three techniques to simulate SAH: (1) an intracranial artery is punctured allowing blood to surround the artery; (2) an artery is surgically exposed and clotted autologous blood obtained from another site is placed around the artery; or (3) autologous blood from another site is injected into the subarachnoid space and allowed to surround the intracranial arteries. Each technique has advantages and disadvantages. In this chapter, we discuss the advantages and disadvantages of and methods for creation of SAH and angiographic vasospasm in non-human primates. Arterial diameters are easily quantified by angiography and SAH is created by frontal craniectomy, exposure of the intracranial arteries of the anterior circle of Willis and placement of autologous clotted blood around these arteries.


Angiographic vasospasm Cerebral angiography Non-human primate Subarachnoid hemorrhage 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • R. Loch Macdonald
    • 1
    • 2
    • 3
  1. 1.Division of NeurosurgerySt. Michael’s HospitalTorontoCanada
  2. 2.Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre for Biomedical ScienceLi Ka Shing Knowledge Institute, St. Michael’s HospitalTorontoCanada
  3. 3.Department of SurgeryUniversity of TorontoTorontoCanada

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