Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits

  • Zhongjie Shi
  • Kehuan Luo
  • Sidhartha Tan
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


Rabbits, like humans, are perinatal brain developers. The model of uterine ischemia mimics acute placental insufficiency states in humans such as placental abruption. A detailed description of the fetal model is presented. Following fetal hypoxia-ischemia, movement disorders are observed in postnatal rabbit kits akin to those observed in cerebral palsy in humans.


Behavior Brain Dystonia Fetus Hypoxia Infant, newborn Infant, premature Ischemia Placental insufficiency Uterus 



Xinhai Ji for his input.

Supported by grants from NIH, HD01138, NS41476, NS43285, NS051402, NS081936, NS100088 (S.T.).


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Zhongjie Shi
    • 1
  • Kehuan Luo
    • 1
  • Sidhartha Tan
    • 1
    • 2
  1. 1.Department of PediatricsWayne State UniversityDetroitUSA
  2. 2.Department of PediatricsChildren’s Hospital of MichiganDetroitUSA

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