Rabbits, like humans, are perinatal brain developers. The model of uterine ischemia mimics acute placental insufficiency states in humans such as placental abruption. A detailed description of the fetal model is presented. Following fetal hypoxia-ischemia, movement disorders are observed in postnatal rabbit kits akin to those observed in cerebral palsy in humans.
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Xinhai Ji for his input.
Supported by grants from NIH, HD01138, NS41476, NS43285, NS051402, NS081936, NS100088 (S.T.).
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