Nutrition, Immunity, and Neurological Diseases

  • Seema Patel


A diverse range of agents, from biological and chemical to mechanical, can be perceived as stressors by the immune system. Even the diet, depending on its components and dosage, can provoke the immune system. Processed foods are acidogenic which lower the pH of the extracellular matrix (ECM), causing an aberrant enzyme activity. The consequent agitated immune system is linked to all pathologies including infections, metabolic disorders, and autoimmune diseases. Disturbed immunity has also been implicated in neuropathologies. Inflammation, which perturbs the neuro-endocrine-immune axis, is the central mechanism related to neural issues. During inflammation, the weapons of the innate immune system, cytokines, produce reactive oxygen species (ROS) and reactive nitrogen species (RNS), which cause damage to the organs. Mapping of disease-specific biomarkers has showed the correlation between the aberrant expression of neural, immune, and metabolic mediators (insulin, leptin, cytokine, angiotensin II, serine protease, aromatase, estrogen, and neurotransmitters) and neural ailments such as multiple sclerosis, depression, autism, and dementia, among others. In this manner, the immunometabolic mechanisms control the neural health through interacting signaling pathways such as the hypothalamic-pituitary-adrenal (HPA) axis and renin-angiotensin-aldosterone system (RAAS). For a clearer picture of these connections, this chapter discusses the nexus between diet, immune system, and neural system.


Immune system Inflammation Nutrition Neurological diseases 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Seema Patel
    • 1
  1. 1.Bioinformatics and Medical Informatics Research CenterSan Diego State UniversitySan DiegoUSA

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