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The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses

  • Kelly L. WormwoodEmail author
  • Liulin Deng
  • Ahmed M. Hamid
  • Daniel DeBord
  • Laura Maxon
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1140)

Abstract

The pharmaceutical and clinical industries are imperative for the maintenance of global health and welfare and require accurate, reproducible, and high throughput analyses. Technological advancements, such as the development and implementation of liquid chromatography-tandem mass spectrometry (LC-MS), have allowed for improvements in these areas, however there is still room for development. One way in which current analyses may be improved is by the implementation of ion mobility technology. Ion mobility has the capability to produce much more comprehensive data sets, by providing separation of isomers, as well as improving throughput, with separations being performed as fast as 60 ms. Here we will discuss the potential for ion mobility to assist in the two specific areas of glycosylation monitoring of biological drugs, and vitamin D analysis, as representatives of ion mobility’s potential in both the pharmaceutical and clinical industries, respectively, as well as the current hurdles of ion mobility adoption in both fields.

Keywords

SLIM (Structures for Lossless Ion Manipulations) Ion mobility Mass spectrometry Vitamin D Glycosylation Pharmaceutical Clinical 

Abbreviations

ACN

Acetonitrile

BLA

Biological License Application

CCS

Collisional cross section

CLIA

Clinical laboratory improvement amendments

CQA

Critical quality attribute

DTIMS

Drift tube ion mobility spectrometry

FA

Formic acid

FAIMS

Field asymmetric ion mobility spectrometry

FDA

Food and Drug Administration

HILIC

Hydrophilic interaction liquid chromatography

IMS

Ion mobility spectrometry

LC

Liquid chromatography

LC-MS

Liquid chromatography-mass spectrometry

MS

Mass spectrometry

RP

Reverse phase

SLIM

Structures for Lossless Ion Manipulations

TIMS

Trapped ion mobility spectrometry

TOF

Time of flight

TWIMS

Traveling wave ion mobility spectrometry

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Kelly L. Wormwood
    • 1
    Email author
  • Liulin Deng
    • 1
  • Ahmed M. Hamid
    • 1
  • Daniel DeBord
    • 1
  • Laura Maxon
    • 1
  1. 1.MOBILion Systems Inc.ExtonUSA

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