Stabilization of Synthetic Materials with Silver Particles

  • Roman MajorEmail author
  • Gabriela Imbir
  • Aldona Mzyk
  • Piotr Wilczek
  • Marek Sanak
  • Jürgen M. Lackner
Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 925)


The work was related to study of the impact of material on the tissue. A synthetic material of the type of tissue analogue was developed. A disadvantage of synthetic materials is their instability, in particularly in the environmental fluids. Within the framework of the statutory test silver nanoparticles deposited by magnetron sputtering were conducted delivering its stabilization. Silver nanoparticles were introduced into the polyelectrolyte structure, in order to reduce the risk of the bacterial biofilm formation. The introduction of Ag nanoparticles was followed by deposition under high vacuum by magnetron sputtering. The analysis of the blood-material interactions was conducted using commercially available tester, Impact-R (Diamed). The assessment of silver ions assessment into plasma was tested based on prothrombin time (PT) and activated partial thromboplastin time (APTT). The unmodified surface of the polyelectrolyte is a potential activator of blood elements. The introduction of silver nanoparticles reduced the likelihood of clotting. Extrinsic coagulation pathway determined on the basis of internal PT and APTT coagulation pathways did not indicate hazards beyond the acceptable range.


Synthetic materials Polyelectrolytes Layer by layer Nanoparticle Deposition Blood-material interaction 



The research was financially supported by the Project no. 2016/23/B/ST8/01481 ‘Interdisciplinary methods of creating and functioning of biomimetic materials based on Animal origin extracellular matrix’ of the Polish National Center of Science. Part of the work was co-financed by NCN: 2014/15/B/ST8/00103 and the European Union from resources of the European Social Fund (Project No. WND-POWR.03.02.00-00-I043/16).


  1. 1.
    Chung, S., King, M.W.: Biotechnol. Appl. Biochem. 58, 423–438 (2011)CrossRefGoogle Scholar
  2. 2.
    Naderi, H., Matin, M.M., Bahrami, A.R.: J. Biomater. Appl. 26, 383–417 (2011)CrossRefGoogle Scholar
  3. 3.
    Richert, L., Boulmedais, F., Lavalle, P., Mutterer, J., Ferreux, E., Decher, G., Schaaf, P., Voegel, J.C., Picart, C.: Biomacromolecules 5(2), 284–294 (2004)CrossRefGoogle Scholar
  4. 4.
    Major, R.: J. Mater. Sci. Mater. Med. 24, 725–733 (2013)CrossRefGoogle Scholar
  5. 5.
    Mzyk, A., Major, R., Kot, M., Gostek, J., Wilczek, P., Major, B.: Arch. Civ. Mech. Eng. 14, 262–268 (2014)CrossRefGoogle Scholar
  6. 6.
    Marx, D.E., Barillo, D.J.: Burns 40S, 9–18 (2014)CrossRefGoogle Scholar
  7. 7.
    Lansdown, G.: Curr. Probl. Dermatol. 33, 17–34 (2006)CrossRefGoogle Scholar
  8. 8.
    Parka, M., Neigh, A.M., Vermeulen, J.P., de la Fonteyne, L., Verharen, H.W., Briedé, J.J., van Loveren, H., de Jong, W.H.: Biomaterials 32, 9810–9817 (2011)CrossRefGoogle Scholar
  9. 9.
    Arvidsson, S., Askendal, A., Tengvall, P.: Biomaterials 28, 1346–1354 (2007)CrossRefGoogle Scholar
  10. 10.
    Horbett, T.A.: The role of adsorbed proteins in tissue response to biomaterials. In: Ratner, B.D., Hoffman, A.S., Schoen, F.J., Lemons, J.E. (eds.) Biomaterials Science: An Introduction to Materials in Medicine, 2nd edn, pp. 237–246. Elsevier Academic Press, London (2004)Google Scholar
  11. 11.
    Brash, J.L., Ten Hove, P.: Thromb. Hemost. 51, 326–330 (1984)CrossRefGoogle Scholar
  12. 12.
    Merrill, E.W.: Distinctions and correspondences among surfaces contacting blood. In: Leonard, E.F., Turitto, V.T., Vroman, L. (eds.) Blood in Contact with Natural and Artificial Surfaces, vol. 516, pp. 196–203. Annals of the New York Academy of Sciences, New York (1987)Google Scholar
  13. 13.
    Hoffman, A.S.: Modification of material surfaces to affect how they interact with blood. In: Leonard, E.F., Turitto, V.T., Vroman, L. (eds.) Blood in Contact with Natural and Artificial Surfaces, vol. 516, pp. 96–101. Annals of the New York Academy of Sciences, New York (1987)Google Scholar
  14. 14.
    Wojciechowski, P., Ten Hove, P., Brash, J.L.: J. Colloid Interface Sci. 111, 455–465 (1986)CrossRefGoogle Scholar
  15. 15.
    Elwing, H., Askendal, A., Lundstrom, I.: J. Biomed. Mater. Res. 21, 1023–1028 (1987)CrossRefGoogle Scholar
  16. 16.
    Picart, C., Lavalle, P., Hubert, P., Cuisinier, F.J.G., Decher, G., Schaaf, P.: Langmuir 17, 12531–12535 (2001)CrossRefGoogle Scholar
  17. 17.
    Major, L., Lackner, J.M., Major, B.: RSC Adv. 4, 21108–21114 (2014)CrossRefGoogle Scholar
  18. 18.
    Wein, M., Sterbinsky, S.A., Bickel, C.A., Schleimer, R.P., Bochner, B.S.: Am. J. Respir. Cell Mol. Biol. 12(3), 315–319 (1995)CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Roman Major
    • 1
    Email author
  • Gabriela Imbir
    • 1
  • Aldona Mzyk
    • 1
  • Piotr Wilczek
    • 2
  • Marek Sanak
    • 3
  • Jürgen M. Lackner
    • 4
  1. 1.Institute of Metallurgy and Materials Science, Polish Academy of SciencesCracowPoland
  2. 2.Foundation for Cardiac Surgery DevelopmentZabrzePoland
  3. 3.Department of MedicineJagiellonian University Medical CollegeCracowPoland
  4. 4.Joanneum Research Forschungs-GmbH, Materials - Functional SurfacesLeobenAustria

Personalised recommendations