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Enriched Plasmas: Concepts and Processing

  • Paloma Tejero
  • Lucía Jáñez
  • Victoria Sunkel
Chapter

Abstract

The increase in life expectancy in the population makes necessary to search for safe and affordable treatments, which improve the quality of life and help to slow down the aging process. Platelet-rich plasma (PRP), as a restorative and autologous treatment, achieves rejuvenating effects, with the application of minimal amounts of blood plasma into the skin, and restores normal metabolism, and cutaneous functions deteriorated over the years, by biological activation of skin cells. Among the many biological materials which are available today, the use of blood plasma has attracted a special interest. Nevertheless, as it was initially considered a minor therapeutic option against cell autotransplant from other tissues, its knowledge and development has been slow [1].

References

  1. 1.
    De Sola Semería L, Tejero P. Factores de crecimiento: Aplicaciones en Medicina Estética. In: Tresguerres JAF, Insua E, Castaño P, Tejero P, editors. Medicina Estética y Antienvejecimiento. 2nd ed. Mexico: Editorial medica Panamericana; 2018. p. 485–504.Google Scholar
  2. 2.
    Kingsley CS. Blood coagulation; evidence of an antagonist to factor VI in platelet-rich human plasma. Nature. 1954;173(4407):723–4.PubMedCrossRefGoogle Scholar
  3. 3.
    Urist M. Bone: formation by autoinduction. Science. 1965;150(3698):893–9.PubMedCrossRefGoogle Scholar
  4. 4.
    Matras H. Effect of various fibrin preparations on reimplantations in the rat skin. Osterr Z Stomatol. 1970;67(9):338–59.PubMedGoogle Scholar
  5. 5.
    Agrawal AA. Evolution, current status and advances in application of platelet concentrate in periodontics and implantology. World J Clin Cases. 2017;5(5):159–71.  https://doi.org/10.12998/wjcc.v5.i5.159.PubMedPubMedCentralCrossRefGoogle Scholar
  6. 6.
    Rosenthal AR, Egbert PR, Harbury C, Hopkins JL, Rubenstein E. Use of platelet-fibrinogen-thrombin mixture to seal experimental penetrating corneal wounds. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978;207(2):111–5.PubMedCrossRefGoogle Scholar
  7. 7.
    Knighton DR, Ciresi KF, Fiegel VD, Austin LL, Butler EL. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg. 1986;204:322–30.PubMedPubMedCentralCrossRefGoogle Scholar
  8. 8.
    Tayapongsak P, O'Brien DA, Monteiro CB, Arceo-Diaz LY. Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral Maxillofac Surg. 1994;52(2):161–5.PubMedCrossRefGoogle Scholar
  9. 9.
    Whitman DH, Berry RL, Green DM. Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 1997;55(11):1294–9.PubMedCrossRefGoogle Scholar
  10. 10.
    Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):638–46.PubMedCrossRefGoogle Scholar
  11. 11.
    Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999;14(4):529–35.PubMedGoogle Scholar
  12. 12.
    Choukroun J, Adda F, Schoeffer C, Vervelle A. PRF: an opportunity in perio implantology. Implantodontie. 2000;42:55–62.Google Scholar
  13. 13.
    Everts PA, van Zundert A, Schönberger JP, Devilee RJ, Knape JT. What do we use: platelet-rich plasma or platelet-leukocyte gel? J Biomed Mater Res A. 2008;85(4):1135–6.PubMedCrossRefGoogle Scholar
  14. 14.
    Everts PA, Hoffmann J, Weibrich G, Mahoney CB, Schönberger JP, van Zundert A, et al. Differences in platelet growth factor release and leucocyte kinetics during autologous platelet gel formation. Transfus Med. 2006;16:363–8.  https://doi.org/10.1111/j.1365-3148.2006.00708.x.PubMedCrossRefGoogle Scholar
  15. 15.
    Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158–67.  https://doi.org/10.1016/j.tibtech.2008.11.009.PubMedCrossRefGoogle Scholar
  16. 16.
    Mishra A, Harmon K, Woodall J, Vieira A. Sports medicine applications of platelet rich plasma. Curr Pharm Biotechnol. 2012;13(7):1185–95.PubMedCrossRefGoogle Scholar
  17. 17.
    DeLong JM, Russell RP, Mazzocca AD. Platelet-rich plasma: the PAW classification system. Arthroscopy. 2012;28(7):998–1009.  https://doi.org/10.1016/j.arthro.2012.04.148.PubMedCrossRefGoogle Scholar
  18. 18.
    Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Fıratlı E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg. 2013;51(5):438–43.  https://doi.org/10.1016/j.bjoms.2012.08.003.PubMedCrossRefGoogle Scholar
  19. 19.
    Choukroun J. Advanced PRF and i-PRF: platelet concentrate or blood concentrate? J Periodontal Med Clin Pract. 2014;1:3.Google Scholar
  20. 20.
    Mourão CF, Valiense H, Melo ER, Mourão NB, Maia MD. Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft: technical note. Rev Col Bras Cir. 2015;42(6):421–3.  https://doi.org/10.1590/0100-69912015006013.PubMedCrossRefGoogle Scholar
  21. 21.
    Guszczyn T, Surażyński A, Zaręba I, Rysiak E, Popko J, Pałka J. Differential effect of platelet-rich plasma fractions on β1-integrin signaling, collagen biosynthesis, and prolidase activity in human skin fibroblasts. Drug Des Devel Ther. 2017;11:1849–57.  https://doi.org/10.2147/DDDT.S135949.PubMedPubMedCentralCrossRefGoogle Scholar
  22. 22.
    Marx G, Ben-Moshe M, Magdassi S, Gorodetsky R. Fibrinogen C-terminal peptidic sequences (Haptides) modulate fibrin polymerization. Thromb Haemost. 2004 Jan;91(1):43–51.PubMedCrossRefGoogle Scholar
  23. 23.
    Zumstein MA, Bielecki T, DohanEhrenfest DM. The future of platelet concentrates in sports medicine: platelet-rich plasma, platelet-rich fibrin, and the impact of scaffolds and cells on the long-term delivery of growth factors. Oper Tech Sports Med. 2011;19:190–7.CrossRefGoogle Scholar
  24. 24.
    Bielecki T, Dohan Ehrenfest DM. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF): surgical adjuvants, preparations for in situ regenerative medicine and tools for tissue engineering. Curr Pharm Biotechnol. 2012;13(7):1121–30.PubMedCrossRefGoogle Scholar
  25. 25.
    Del Corso M, Vervelle A, Simonpieri A, Jimbo R, Inchingolo F, Sammartino G, Dohan Ehrenfest DM. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: periodontal and dentoalveolar surgery. Curr Pharm Biotechnol. 2012;13(7):1207–30.PubMedCrossRefGoogle Scholar
  26. 26.
    Leitner GC, Gruber R, Neumüller J, Wagner A, Kloimstein P, Höcker P, et al. Platelet content and growth factor release in platelet-rich plasma: a comparison of four different systems. Vox Sang. 2006;91(2):135–9.  https://doi.org/10.1111/j.1423-0410.2006.00815.x.PubMedCrossRefGoogle Scholar
  27. 27.
    Cieslik-Bielecka A, Bielecki T, Gazdzik TS, Arendt J, Król W, Szczepanski T. Autologous platelets and leukocytes can improve healing of infected high-energy soft tissue injury. Transfus Apher Sci. 2009;41(1):9–12.  https://doi.org/10.1016/j.transci.2009.05.006.PubMedCrossRefGoogle Scholar
  28. 28.
    Choukroun J, Adda F, Schoeffer C, Vervelle A. Une opportunité en paro-implantologie: le PRF. Implantodontie. 2001;42:55–62.Google Scholar
  29. 29.
    Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:37–44.  https://doi.org/10.1016/j.tripleo.2005.07.008.CrossRefGoogle Scholar
  30. 30.
    Sohn DS. Lecture titled with sinus and ridge augmentation with CGF and AFG, Symposium on CGF and AFG. Tokyo, 2010.Google Scholar
  31. 31.
    Dohan Ehrenfest DM, Bielecki T, Mishra A, Borzini P, Inchingolo F, Sammartino G, et al. In search of a consensus terminology in the field of platelet concentrates for surgical use: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes. Curr Pharm Biotechnol. 2012;13(7):1131–7.PubMedCrossRefGoogle Scholar
  32. 32.
    Fukaya M, Ito A. A new economic method for preparing platelet-rich plasma. Plast Reconstr Surg Glob Open. 2014;2(6):e162.  https://doi.org/10.1097/GOX.0000000000000109.PubMedPubMedCentralCrossRefGoogle Scholar
  33. 33.
    Mautner K, Malanga G, Smith J, Shiple B, Ibrahim V, Sampson S, et al. A call for a standard classification system for future biologic research: the rationale fornew PRP nomenclature. Am J Phys Med Rehabil. 2015;7(4 Suppl):S53–9.  https://doi.org/10.1016/j.pmrj.2015.02.005.CrossRefGoogle Scholar
  34. 34.
    Magalon J, Chateau AL, Bertrand B, Louis ML, Silvestre A, Giraudo L, et al. DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices. BMJ Open Sport Exerc Med. 2016;2(1):e000060. eCollection 2016.  https://doi.org/10.1136/bmjsem-2015-000060.PubMedPubMedCentralCrossRefGoogle Scholar
  35. 35.
    Lana JFSD, Purita J, Paulus C, Huber SC, Rodrigues BL, Rodrigues AA, et al. Contributions for classification of platelet rich plasma-proposal of a new classification:MARSPILL. Regen Med. 2017;12(5):565–74.  https://doi.org/10.2217/rme-2017-0042.PubMedCrossRefGoogle Scholar
  36. 36.
    Carrillo-Mora P, González-Villalva A, Macías-Hernández SI, Villaseñor CP. Platelet-rich plasma: a versatile tool for regenerative medicine? Cir Cir. 2013;81(1):74–82.PubMedGoogle Scholar
  37. 37.
    Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost. 2011;105(Suppl 1):S13–33.  https://doi.org/10.1160/THS10-11-0720.PubMedCrossRefGoogle Scholar
  38. 38.
    El-Sharkawy H, Kantarci A, Deady J, Hasturk H, Liu H, Alshahat M, Van Dyke TE. Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties. J Periodontol. 2007;78(4):661–9.  https://doi.org/10.1902/jop.2007.060302.PubMedCrossRefGoogle Scholar
  39. 39.
    Fioravanti C, Frustaci I, Armellin E, Condò R, Arcuri C, Cerroni L. Autologous blood preparations rich in platelets, fibrin and growth factors. Oral Implantol. 2015;8(4):96–113.  https://doi.org/10.11138/orl/2015.8.4.096.CrossRefGoogle Scholar
  40. 40.
    Ferrara N, Gerber HP. The role of vascular endothelial growth factor in angiogenesis. Acta Haematol. 2001;106:148–56.  https://doi.org/10.1159/000046610.PubMedCrossRefGoogle Scholar
  41. 41.
    Einhorn TA. The science of fracture healing. J Orthop Trauma. 2005;19(10):4–6.CrossRefGoogle Scholar
  42. 42.
    Alves R, Grimalt R. A review of platelet-rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord Epub. 2017;  https://doi.org/10.1159/000477353.PubMedPubMedCentralCrossRefGoogle Scholar
  43. 43.
    Cole BJ, Seroyer ST, Filardo G, Bajaj S, Fortier LA. Platelet-rich plasma: where are we now and where are we going? Sports Health. 2010;2(3):203–10.  https://doi.org/10.1177/1941738110366385.PubMedPubMedCentralCrossRefGoogle Scholar
  44. 44.
    Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med. 2003;33(5):381–94.PubMedCrossRefGoogle Scholar
  45. 45.
    Blair P, Flaumenhaft R. Platelet alpha-granules: basic biology and clinical correlates. Blood Rev. 2009;23(4):177–89.  https://doi.org/10.1016/j.blre.2009.04.001.PubMedPubMedCentralCrossRefGoogle Scholar
  46. 46.
    Marx RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent. 2001;10(4):225–8.PubMedCrossRefGoogle Scholar
  47. 47.
    Kim DH, Je YJ, Kim CD, Lee YH, Seo YJ, Lee JH, et al. Can platelet-rich plasma be used for skin rejuvenation. Evaluation of effects of platelet-rich plasma on human dermal fibroblast. Ann Dermatol. 2011;23(4):424–31.  https://doi.org/10.5021/ad.2011.23.4.424.PubMedPubMedCentralCrossRefGoogle Scholar
  48. 48.
    Le Pillouer-Prost A. Fibroblasts: whats new in cellular biology? J Cosmet Laser Ther. 2003;5(3-4):232–8.  https://doi.org/10.1080/14764170310021869.PubMedCrossRefGoogle Scholar
  49. 49.
    Kim WS, Park BS, Park SH, Kim HK, Sung JH. Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors. J Dermatol Sci. 2009;53(2):96–102.  https://doi.org/10.1016/j.jdermsci.2008.08.007.PubMedCrossRefGoogle Scholar
  50. 50.
    Mehta-Ambalal SR. Neocollagenesis and neoelastinogenesis: from the laboratory to the clinic. J Cutan Aesthet Surg. 2016;9(3):145–51.  https://doi.org/10.4103/0974-2077.191645.PubMedPubMedCentralCrossRefGoogle Scholar
  51. 51.
    Kakudo N, Minakata T, Mitsui T, Kushida S, Notodihardjo FZ, Kusumoto K. Proliferation-promoting effect of platelet rich plasma on human adipose-derived stem cells and human dermal fibroblasts. Plast Reconstr Surg. 2008;122(5):1352–60.  https://doi.org/10.1097/PRS.0b013e3181882046.PubMedCrossRefGoogle Scholar
  52. 52.
    Redaelli A, Romano D, Marcianó A. Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol. 2010;9(5):466–72.PubMedGoogle Scholar
  53. 53.
    Dhurat R, Sukesh M. Principles and methods of preparation of platelet-rich plasma: a review and author’s perspective. J Cutan Aesthet Surg. 2014;7(4):189–97.  https://doi.org/10.4103/0974-2077.150734.PubMedPubMedCentralCrossRefGoogle Scholar
  54. 54.
    Arshdeep KMS. Platelet-rich plasma in dermatology: boon or a bane? Indian J Dermatol Venereol Leprol. 2014;80(1):5–14.  https://doi.org/10.4103/0378-6323.125467.CrossRefGoogle Scholar
  55. 55.
    Anitua E, Sánchez M, Orive G. The importance of understanding what is platelet-rich growth factor (PRGF) and what is not. J Shoulder Elb Surg. 2011;20:e23–4.  https://doi.org/10.1016/j.jse.2010.07.005.CrossRefGoogle Scholar
  56. 56.
    Rozman P, Bolta Z. Use of platelet growth factors in treating wounds and soft-tissue injuries. Acta Dermatovenerol Alp Pannonica Adriat. 2007;16(4):156–65.PubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Paloma Tejero
    • 1
  • Lucía Jáñez
    • 2
  • Victoria Sunkel
    • 3
  1. 1.University of AlcaláMadridSpain
  2. 2.Instituto de Tecnología del Conocimiento—Complutense University (UCM)MadridSpain
  3. 3.Mediestetic MadridMadridSpain

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