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Microneedle Patch to Deliver Collagen Through the Skin

  • Jaspreet Singh Kochhar
  • Justin J. Y. Tan
  • Yee Chin Kwang
  • Lifeng Kang
Chapter

Abstract

Micromolding, one of the most commonly used technique for fabricating polymeric microneedles, often requires multiple procedures and the use of toxic SU-8 epoxy chemicals. In Chap.  3, photolithography using photomasks was proposed as an alternative to fabricate polymeric microneedles in a single-step and mould-free process. However, microneedles produced from this method had a larger tip diameter, which can potentially lower its penetration efficiency through the skin. Herein this chapter, we developed a simple photolithographical process using microlenses to fabricate polymeric microneedles of increased tip sharpness. We have demonstrated that the microneedles were able to puncture excised rat skin effectively when inserted with the force of a thumb, thereby withstanding high levels of compressive force. In addition, we have also shown that collagen can be delivered transdermally up to the dermis layer in order to achieve its cosmetic/pharmacological effect. This approach of fabricating microneedles may pave the way for future transdermal delivery of proteins and other macromolecules for localized effect within the skin layers.

Keywords

Microlense Collagen Dermis Micromolding 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jaspreet Singh Kochhar
    • 1
  • Justin J. Y. Tan
    • 2
  • Yee Chin Kwang
    • 3
  • Lifeng Kang
    • 3
  1. 1.Procter & GambleSingaporeSingapore
  2. 2.Department of PharmacyNational University of SingaporeSingaporeSingapore
  3. 3.School of PharmacyUniversity of SydneySydneyAustralia

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