Abstract
Women are typically from two to three times more likely to develop depressive disorders than men are. The gender difference emerges earlier than previously thought, at the age of 12. It peaks in adolescence and declines in adulthood, remaining stable until senescence, when a small peak occurs.
Depression is a multifactorial disorder so, its etiology cannot be dissociated from the socioeconomic and cultural environment, having a great importance on the current gender construct. Despite the fact that genetic vulnerability and sex hormones have been considered the main causal factors of this difference, nowadays some other factors are taken into account, such as emotion regulation strategies (women are more likely to ruminate, while men tend to suppress or avoid their emotions) and changes in the classical personality features attributed to men and women (“depressive temperament”) and in the sex role (chronic stresses associated with traditional female roles lead to a higher prevalence of depression).
Attending to the way of presentation, depressed women are more likely to exhibit “atypical” symptoms and more anxiety and somatization.
Great differences have not been found regarding to the response to pharmacological treatment according to gender. In the case of psychotherapy, cognitive-behavioral treatment has been most empirically demonstrated to be effective on both sexes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
American Psychiatric Association, editor. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Association; 2013.
Sadock BJ, Kaplan HI, Sadock VA. Kaplan & Sadock synopsis of psychiatry. Philadelphia, PA: Wolters Kluwer España; 2015.
GBD. Disease and Injury incidence and prevalence collaborators and others. Global, regional and national incidence, prevalence and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Gobal Burden of Disease Sutudy 2015. Lancet. 2015;388:10053.
Barbieri NB. Psychoanalytic contributions to the study of gender issues. Can J Psychiatr. 1999;44(1):72–6.
World Health Organization. World Health Survey. 2017.
Ferrari AJ, Somerville AJ, Baxter AJ, Norman R, Pattern SB, Vos R, Whiteford HA. Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature. Psychol Med. 2013;43(3):471–81.
Murphy JA, et al. Prevalence and correlates of the proposed DSM-5 diagnosis of Chronic Depressive Disorder. J Affect Disord. 2012;139(2):172–80.
Harvard Medical School, 2007. National Comorbidity Survey. 2017.
Weissman NM, Klerman GL. Sex differences and the epidemiology of depression. Arch Gen Psychiatry. 1977;34:98–111.
Bromet E, Andrade LH, Hwang I, Sampson NA, Alonso J, de Girolamo G, Kessler RC. Cross-national epidemiology of DSM-IV major depressive episode. BMC Med. 2011;9:90.
Salk RH, Hyde JS, Abramson LY. Gender differences in depression in representative national samples: meta-analyses of diagnoses and symptoms. Psychol Bull. 2017;143(8):783–822.
Hankin B. Development of sex differences in depressive and co-occurring anxious symptoms during adolescence: descriptive trajectories and potential explanations in a multiwave prospective study. J Clin Child Adolesc Psychol. 2009;38:460–72.
Lewinsohn PM, Solomon A, Seeley JR, Zeiss A. Clinical implications of “subthreshold” depressive symptoms. J Abnorm Psychol. 2000;109(2):345–51.
Klein DN, Shankman SA, Lewinsohn PM, Seeley JR. Subthreshold depression in adolescents: predictors of escalation to full syndrome depressive disorders. J Am Acad Child Adolesc Psychiatry. 2009;48:703–10.
Garrison CZ, Waller JL, Cuffe SP, McKeown RE, Addy CL, Jackson KL. Incidence of major depressive disorder and dysthymia in young adolescents. J Am Acad Child Adolesc Psychiatry. 1997;36(4):458–65.
Freeman E, Sammel M, Boorman D, Zhang R. Longitudinal pattern of depressive symptoms around natural menopause. JAMA Psychiat. 2014;71:36–43.
Hyde JS, Mezulis AH, Abramson LY. The ABCs of depression: integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depression. Psychol Rev. 2008;115:291–313.
Piccinelli M, Wilkinson G. Gender differences in depression. Critical review. Br J Psychiatry. 2000;177:486–92.
Nolen-Hoeksema S. Emotion regulation and psychopathology: the role of gender. Annu Rev Clin Psychol. 2012;8:161–87.
Zahn-Waxler C, Crick NR, Shirtcliff EA, Woods KE. The origins and development of psychopathology in females and males. In: Cohen D, Cicchetti D, editors. Handbook of developmental psychopathology. Hoboken, NJ: Wiley; 2006. p. 76–139.
Kravitz H, Schott L, Joffe H, Cyranowski J, Bromberger J. Do anxiety symptoms predict major depressive disorder in midlife women? The Study of Women’s Health Across the Nation (SWAN) Mental Health Study (MHS). Psychol Med. 2014;44:2593–602.
Martel M. Sexual selection and sex differences in the prevalence of childhood externalizing and adolescent internalizing disorders. Psychol Bull. 2013;139:1221–59.
Aldao A, Nolen-Hoeksema S, Schweizer S. Emotion-regulation strategies across psychopathology: a meta-analytic review. Clin Psychol Rev. 2010;30(2):217–37.
Jose PE, Kljakovic M, Scheib E, Notter O. The joint development of traditional bullying and victimization with cyberbullying and victimization in adolescence. J Res Adolesc. 2011;22:301–9.
American Psychological Association. Report of the task force on the sexualization of girls. Washington, DC: American Psychological Association; 2007.
Graff KA, Murnen SK, Krause AK. Low-cutshirts and highheeled shoes: increased sexualization across time in magazine depictions of girls. Sex Roles. 2013;69(11–12):571–82.
Bor W, Dean AJ, Najman J, Hayatbakhsh R. Are child and adolescent mental health problems increasing in the 21st century? A systematic review. Aust N Z J Psychiatry. 2014;48:606–16.
Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. A population-based twin study of major depression in women. The impact of varying definitions of illness. Arch Gen Psychiatry. 1992;49(4):257–66.
Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. A longitudinal twin study of 1-year prevalence of major depression in women. Arch Gen Psychiatry. 1993;50(11):843–52.
Silberg J, Pickles A, Rutter M, Hewitt J, Simonoff E, Maes H, Carbonneau R, Murrelle L, Foley D, Eaves L. The influence of genetic factors and life stress on depression among adolescent girls. Arch Gen Psychiatry. 1999;56(3):225–32.
Accortt EE, Freeman MP, Allen JJ. Women and major depressive disorder: clinical perspectives on causal pathways. J Womens Health (Larchmt). 2008;17(10):1583–90.
Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631):386–9.
Eley TC, Sugden K, Corsico A, Gregory AM, Sham P, McGuffin P, Plomin R, Craig IW. Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry. 2004;9(10):908–15.
Bundío BL, Rahola GJ. Trastornos depresivos en la mujer. In: Leal C, editor. Tratamiento de los trastornos afectivos en la mujer. Barcelona: Masson; 1999. p. 189–234.
Kornstein SG, Sloan DM, Thase ME. Gender-specific differences in depression and treatment response. Psychopharmacol Bull. 2002;36(4 Suppl 3):99–112.
Hankin BL, et al. Depression from childhood into late adolescence: influence of gender, development, genetic susceptibility, and peer stress. J Abnorm Psychol. 2015;124:803–16.
Salk RH, Petersen JL, Abramson LY, Hyde JS. The contemporary face of gender differences and similarities in depression throughout adolescence: development and chronicity. J Affect Disord. 2016;205:28–35.
Ge X, Conger RD, Elder JH Jr. Pubertal transition, stressful life events, and the emergence of gender differences in adolescent depressive symptoms. Dev. Psychol. 2001;37(3):404–17.
Klaiber EL, Broverman DM, Vogel W, Kobayashi Y. Estrogen therapy for severe persistent depressions in women. Arch Gen Psychiatry. 1979;36(5):550–4.
Biegon A, McEwen BS. Modulation by estradiol of serotonin receptors in brain. J Neurosci. 1982;2(2):199–205.
Pajer K. New strategies in the treatment of depression in women. J Clin Psychiatry. 1995;56(Suppl 2):30–7.
Cohen IR, Wise PM. Effects of estradiol on the diurnal rhythm of serotonin activity in microdissected brain areas of ovariectomized rats. Endocrinology. 1988;122(6):2619–25.
Seidman SN. The neuroendocrine system in late life. In: Roose SP, Sackeim HA, editors. Late-life depression. New York: Oxford University Press; 2004. p. 167–81.
Epperson C, Sammel M, Freeman E. Menopause effects on verbal memory: findings from a longitudinal community cohort. J Clin Endocrinol Metab. 2013;98:3829–38.
Epperson C, Sammel M, Scalice S, Conlin R, Freeman E. Early life adversity increases risk of new onset depression during the menopause transition. In: Annual Meeting of the American College of Neuropsychopharmacology, Hollywood, FL. 2013.
Schiller CE, et al. The role of reproductive hormones in postpartum depression. CNS Spectr. 2015;20(1):48–59.
Vesga-Lopez O, Blanco C, Keyes K, Olfson M, Grant BF, Hasin DS. Psychiatric disorders in pregnant and postpartum women in the United States. Arch Gen Psychiatry. 2008;65:805–15.
Skalkidou A, Hellgren C, Comasco E, Sylven S, Sundström Poromaa I. Biological aspects of postpartum depression. Womens Health. 2012;8:659–72.
Soares CN. Mood disorders in midlife women: understanding the critical window and its clinical implications. Menopause. 2014;21:198–206.
Lombardo M, Ashwin E, Auyeung B, Chakrabarti B, Lai MC, Taylor K, Hackett G, Bullmore E, Baron-Cohen S. Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans. Biol Psychiatry. 2012;72:839–47.
Jaworska N, Yang X, Knott V, Macqueen G. A review of fMRI studies during visual emotive processing in major depressive disorder. World J Biol Psychiatry. 2014;16:448–71.
Soares CN, Zitek B. Reproductive hormone sensitivity and risk for depression across the female life cycle: a continuum of vulnerability? J Psychiatry Neurosci. 2008;33:331–43.
Goldstein JM, Holsen L, Handa R, Tobet S. Fetal hormonal programming of sex differences in depression: linking women’s mental health with sex differences in the brain across the lifespan. Front Neurosci. 2014;8:247.
Buss C, Davis E, Shahbaba B, Pruessner J, Head K, Sandman C. Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems. Proc Natl Acad Sci. 2012;109:1312–9.
Sandman C, Glynn L, Davis E. Is there a viability-vulnerability tradeoff? Sex differences in fetal programming. J Psychosom Res. 2013;75:327–35.
Grey K, Davis E, Sandman C, Glynn L. Human milk cortisol is associated with infant temperment. Psychoneuroendocrinology. 2012;38:1178–85.
Susan Nolen-Hoeksema S, Wisco BE, Lyubomirsky S. Rethinking rumination. Perspect Psychol Sci. 2008;3(5):400–24.
Barrett LF, Bliss-Moreau E. She’s emotional. He’s having a bad day: attributional explanations for emotion stereotypes. Emotion. 2009;9(5):649–58.
Barret LF, Lane RD, Sechrest L, Schwartz GE. Sex differences in emotional awareness. Personal Soc Psychol Bull. 2000;26:3–29.
Rose AJ, Carlson W, Waller EM. Prospective associations of co-rumination with friendship and emotional adjustment: considering the socioemotional trade-offs of co-rumination. Dev Psychol. 2007;43(4):1019–31.
Nolen-Hoeksema S. Sex differences in unipolar depression: evidence and theory. Psychol Bull. 1987;101(2):259–82.
Lazarevich I, Mora-Carrasco F. Depresión y género: factores psicosociales de riesgo. Salud Problema, segunda época. 2008;1(4):9–18.
Gur R, Richard J, Calkins M, Chiavacci R, Hansen J, Bilker W, Loughead J, Connolly J, Qiu H, Mentch F, Abou-Sleiman P, Hakonarson H, Gur R. Age group and sex differences in performance on a computerized neurocognitive battery in children age 8–21. Neuropsychology. 2012;26:251–65.
Thompson A, Voyer D. Sex differences in the ability to recognise non-verbal displays of emotion: a metaanalysis. Cognit Emot. 2014;28:1164–95.
Nazroo JY, Edwards AC, Brown GW. Gender differences in the onset of depression following a shared life event: a study of couples. Psychol Med. 1997;27(1):9–19.
Brückner H, Mayer KU. De-standardization of the life course: what it might mean? And if it means anything, whether it actually took place? Adv Life Course Res. 2005;9:27–53.
Reiss F. Socioeconomic inequalities and mental health problems in children and adolescents: a systematic review. Soc Sci Med. 2013;90:24–31.
Belle D, Doucet J. Poverty, inequality, and discrimination as sources of depression among U. S. women. Psychol Women Q. 2003;27:1–12.
Koss MP, Goodman LA, Browne A, Fitzgerald LF, Russo NF, Keita GP. No safe haven: male violence against women at home, at work, and in the community. Washington, DC: American Psychological Association; 1994.
Viveros M, Bernal M, Gómez F, Serna G. Masculinidades y violencia intrafamiliar en Colombia. Texto final de la consultoría presentada a la Consejería para la Política Social-Política de Construcción de Paz y Conciencia Familiar. Santafé de Bogotá: s.n. 2000.
Echeburúa E, de Corral P, Amor PJ, Sarasua B, Zubizarreta I. Repercusiones psicopatológicas de la violencia doméstica en la mujer: un estudio descriptivo. Revista de Psicopatología y Psicología Clínica. 1997;2(1):7–19.
Walker LEA. The battered woman syndrome. New York: Springer; 1984/2000.
Ferrando Bundío L. Salud Mental y Género en la práctica clínica. Ars Médica s.l. 2007.
Wood W, Eagly AH. Biosocial construction of sex differences and similarities in behavior. Adv Exp Soc Psychol. 2012;46:55–123.
Pérez Blasco J, Serra DE. Influencia del rol tradicional femenino en la sintomatología ansiosa en una muestra de mujeres adultas. Anales de psicología. 1997;13(2):155–61.
Hopcroft RL, Bradley DB. The sex difference in depression across 29 countries. Soc Forces. 2007;85:1483–507.
Van de Velde S, Huijts T, Bracke P, Bambra C. Macro-level gender equality and depression in men and women in Europe. Sociol Health Illness. 2013;35(5):682–98.
Barberá E, et al. Psicología y género. Madrid: Pearson Prentice Hall; 2004.
Medina-Mora ME, Borges G, Lara C, Benjet C, Blanco J, et al. Prevalencia de trastornos mentales y uso de servicios: Resultados de la Encuesta Nacional de Epidemiología Psiquiátrica en México. Salud Mental. 2003;26:1–16.
Walters V, McDonough P, Strohschein L. The influence of work, household structure, and social, personal and material resources on gender differences in health: an analysis of the 1994 Canadian National Population Health Survey. Soc Sci Med. 2002;54(5):677–92.
Pudrovska T, Karraker A. Gender, job authority and depression. J Health Soc Behav. 2014;55(4):424–41.
Patten SB, Williams JV, Lavorato DH, Eliasziw M. Major depression and injury risk. Can J Psychiatr. 2010;55:313–8.
Frackiewicz EJ, Sramek JJ, Cutler NR. Gender differences in depression and antidepressant pharmacokinetics and adverse events. Ann Pharmacother. 2000;34:80–8.
Keers R, Aitchison KJ. Gender differences in antidepressant drug response. Int Rev Psychiatry. 2010;22:485–500.
Theorell T, Hammarstrom A, Gustafsson PE, Magnusson Hanson L, Janlert U, Westerlund H. Job strain and depressive symptoms in men and women: a prospective study of the working population in Sweden. J Epidemiol Community Health. 2014;68:78–82.
Jaeyoung K, Choi Y. Gender differences in the longitudinal association between work-related injury and depression. Int J Environ Res Public Health. 2016;13(11):1077.
Hirshbein LD. American Melancholy: constructions of depression in the twentieth century. New Brunswick: Rutgers University Press; 2009.
Simonelli L, Heinberg LJ. Gender and minority mental health: the case of body image. In: Loue S, Sajatovic M, editors. Determinants of minority mental health and wellness. New York: Springer; 2009. p. 193–219.
Neitzke AB. An illness of power: gender and the social causes of depression. Cult Med Psychiatry. 2016;40(1):59–73.
Entringer S, Buss C, Shirtcliff E, Cammack A, Yim I, Chicz-DeMet A, Sandman C, Wadhwa P. Attenuation of maternal psychophysiological stress responses and the maternal cortisol awakening response over the course of human pregnancy. Stress. 2010;13:258–68.
Cohen LS, Altshuler LL, Harlow BL, Nonacs R, Newport DJ, Viguera AC, Suri R, Burt VK, Hendrick V, Reminick AM, Loughead A, Vitonis AF, Stowe ZN. Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment. JAMA. 2006;295:499–507.
Munk-Olsen T, Laursen TM, Mendelson T, Pedersen CB, Mors O, Mortensen PB. Risks and predictors of readmission for a mental disorder during the postpartum period. Arch Gen Psychiatry. 2009;66:189–95.
Esscher A, Essen B, Innala E, Papadopoulos FC, Skalkidou A, Sundström-Poromaa I, Hogberg U. Suicides during pregnancy and 1 year postpartum in Sweden, 1980–2007. Br J Psychiatry. 2015;208:462–9.
Altemus M, Neeb C, Davis A, Occhiogrosso M, Nguyen T, Bleiberg K. Phenotypic differences between pregnancy-onset and postpartum-onset major depressive disorder. J Clin Psychiatry. 2013;73:e1485–91.
Moreno Fernández A, Rodríguez Vega B, Carrasco Galán MJ, Sánchez Hernández JJ. Relación de pareja y sintomatología depresiva de la mujer: implicaciones clínicas desde una perspectiva de género. Apuntes de Psicología. 2009;27:489–506.
Blanco C, Vesga-Lopez O, Stewart J, Liu S, Grant B, Hasin D. Epidemiology of major depression with atypical features: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). J Clin Psychiatry. 2012;73:224–32.
Haley C, Sung S, Rush A, Trivedi M, Wisniewski S, Luther J, Kornstein S. The clinical relevance of self-reported premenstrual worsening of depressive symptoms in the management of depressed outpatients: a STAR*D report. J Women’s Health. 2013;22:219–29.
Gold PWCG. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol Psychiatry. 2002;7:254–75.
Klink R, Robichaud M, Debonnel G. Gender and gonadal status modulation of dorsal raphe nucleus serotonergic neurons. Part I: effects of gender and pregnancy. Neuropharmacology. 2002;43:1119–28.
Herbison AE. Estrogen regulation of GABA transmission in rat preoptic area. Brain Res Bull. 1997;44(4):321–6.
Antonijevic IA. Depressive disorders—is it time to endorse different pathophysiologies? Psychoneuroendocrinology. 2006;31(1):1–15.
Angst J, Dobler-Mikola A. The Zurich Study: a prospective epidemiological study of depressive, neurotic and psychosomatic syndromes. IV. Recurrent and nonrecurrent brief depression. Eur Arch Psychiatry Neurol Sci. 1985;234(6):408–16.
Birmaher B, Williamson DE, Dahl DE, Axelson DA, Kaufman J, Dorn LD, Ryan NR. Clinical presentation and course of depression in youth: does onset in childhood differ from onset in adolescence? J Am Acad Child Adolesc Psychiatry. 2004;43:63–70.
Bangasser D, Valentino R. Sex differences in stress-related psychiatric disorders: neurobiological perspectives. Front Neuroendocrinol. 2014;35:303–19.
Amenson CS, Lewinsohn PM. An investigation into the observed sex difference in prevalence of unipolar depression. J Abnorm Psychol. 1981;90(1):1–13.
Lewinsohn PM, Zeiss AM, Duncan EM. Probability of relapse after recovery from an episode of depression. J Abnorm Psychol. 1989;98(2):107–16.
Lewinsohn PM, Pettit JW, Joiner TE Jr, Seeley JR. The symptomatic expression of major depressive disorder in adolescents and young adults. J Abnorm Psychol. 2003;112(2):244–52.
Kovacs M. Gender and the course of major depressive disorder through adolescence in clinically referred youngsters. J Am Acad Child Adolesc Psychiatry. 2001;40(9):1079–85.
Barnett RC, Brennan RT, Marshall NL. Gender and the relationship between parent role quality and psychological distress: a study of men and women in dual-earner couples. J Fam Issues. 1995;15:229–52.
Kessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB. Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity and recurrence. J Affect Disord. 1993;29(2–3):85–96.
Rohde P, Lewinsohn PM, Seeley JR. Are adolescents changed by an episode of major depression? J Am Acad Child Adolesc Psychiatry. 1994;33(9):1289–98.
Nolen-Hoeksema S. The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. J Abnorm Psychol. 2000;109(3):504–11.
Teasdale JD. Cognitive vulnerability to persistent depression. Cognit Emot. 1988;2:247–74.
Jansson M, Gatz M, Berg S, Johansson B, Malmberg B, McClearn GE, Schalling M, Pedersen NL. Gender differences in heritability of depressive symptoms in the elderly. Psychol Med. 2004;34(3):471–9.
Kendler KS, Gatz M, Gardner CO, Pedersen NL. A Swedish national twin study of lifetime major depression. Am J Psychiatry. 2006;163:109–14.
Joiner T, Coyne JC, editors. The interactional nature of depression: advances in interpersonal approaches. Washington, DC: American Psychological Association; 1999.
Post RM, Weiss SRB. Neurobiology of treatment-resistant mood disorders. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology. The fourth generation of progress. New York: Raven Press; 1994. p. 1155–70.
Merikangas K, Gelernter C. Comorbidity for alcoholism and depression. Psychiatr Clin N Am. 1990;13:613–32.
Perkonigg A, Lieb R, Wittchen HU. Dependence of illicit drugs among adolescents and young adults in a community sample. Eur Addict Res. 1998;4:58–66.
Swendsen JD, Merikangas KR. The comorbidity of depression and substance use disorders. Clin Psychol Rev. 2000;20:173–89.
Kinnier RT, Metha AT, Okey JL, Keim J. Adolescent substance abuse and psychological health. J Alcohol Drug Educ. 1994;40:51–5.
Quitkin FM, Stewart JW, McGrath PJ, Taylor BP, Tisminetzky MS, Petkova E, Chen Y, Ma G, Klein DF. Are there differences between women’s and men’s antidepressant responses? Am J Psychiatry. 2002;159(11):1848–54.
Hildebrandt MG, Steyerberg EW, Stage KB, Passchier J, Kragh-Soerensen P, Danish University Antidepressant Group. Are gender differences important for the clinical effects of antidepressants? Am J Psychiatry. 2003;160(9):1643–50.
Davidson J, Pelton S. Forms of atypical depression and their response to antidepressant drugs. Psychiatry Res. 1986;17(2):87–95.
Sramek JJ, Murphy MF, Cutler NR. Sex differences in the psychopharmacological treatment of depression. Dial Clin Neurosci. 2016;18:447–57.
Williams AV, et al. The impact of sex as a biological variable in the search for novel antidepressants. Front Neuroendocrinol. 2018;50:107–17.
Noordam R, Aarts N, Tiemeier H, Hofman A, Stricker BH, Visser LE. Sex-specific association between antidepressant use and body weight in a population-based study in older adults. J Clin Psychiatry. 2015;76(6):e745–51.
Young EA, Kornstein SG, Marcus SM, et al. Sex differences in response to citalopram: a STAR*D report. J Psychiatr Res. 2009;43(5):503–11.
Kornstein SG, Pedersen RD, Holland PJ, et al. Influence of sex and menopausal status on response, remission, and recurrence in patients with recurrent major depressive disorder treated with venlafaxine extended release or fluoxetine: analysis of data from the PREVENT study. J Clin Psychiatry. 2014;75(1):62–8.
Cheung C, Yu AM, Ward JM, Krausz KW, Akiyama TE, Feigenbaum L, Gonzalez FJ. The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. Drug Metab Dispos. 2005;33(3):449–57.
Relling MV, Lin JS, Ayers GD, Evans WE. Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities. Clin Pharmacol Ther. 1992;52(6):643–58.
Jin Y, Pollock BG, Frank E, Cassano GB, Rucci P, Müller DJ, et al. Effect of age, weight, and CYP2C19 genotype on escitalopram exposure. J Clin Pharmacol. 2010;50(1):62–72.
Hägg S, Spigset O, Dahlqvist R. Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers. Br J Clin Pharmacol. 2001;51(2):169–73.
Laine K, Tybring G, Bertilsson L. No sex-related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects. Clin Pharmacol Ther. 2000;68(2):151–9.
Tamminga WJ, Wemer J, Oosterhuis B, Wieling J, Wilffert B, de Leij LFMH, de Zeeuw RA, Jonkman JHG. CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptive-related gender differences. Eur J Clin Pharmacol. 1999;55:177–84.
Kuo HW, Liu SC, Tsou HH, et al. CYP1A2 genetic polymorphisms are associated with early antidepressant escitalopram metabolism and adverse reactions. Pharmacogenomics. 2013;14(10):1191–201.
Ilic K, Hawke RL, Thirumaran RK, et al. The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans. Drug Metab Dispos. 2013;41(3):575–81.
Hiemke C, Härtter S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol Ther. 2000;85:11–28.
Gex-Fabry M, Eap CB, Oneda B, et al. CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response. Ther Drug Monit. 2008;30:474–82.
Reis M, Lundmark J, Bengtsson F. Therapeutic drug monitoring of racemic citalopram: a 5-year experience in Sweden, 1992–1997. Ther Drug Monit. 2003;25:183–91.
Gupta B, Keers R, Uher R, McGuffin P, Aitchison KJ. Pharmacogenetics of antidepressant response. In: Pariante C, Nesse RM, Nutt D, Wolpert L, editors. Understanding depression: a translational approach. Oxford: Oxford University; 2009.
Serretti A, Kato M, De Ronchi D, Kinoshita T. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Mol Psychiatry. 2007;12:247–57.
Mrazek DA, Rush AJ, Biernacka JM, et al. SLC6A4 variation and citalopram response. Am J Med Genet B Neuropsychiatr Genet. 2008;150:341–51.
Huezo-Diaz P, Uher R, Smith R, Rietschel M, Henigsberg N, Marus A, et al. Moderation of antidepressant response by the serotonin transporter gene in the GENDEP study. Br J Psychiatry. 2009;195:30–8.
Schmidt PJ, Murphy JH, Haq N, Danaceau MA, St Clair L. Basal plasma hormone levels in depressed perimenopausal women. Psychoneuroendocrinology. 2002;27(8):907–20.
Morgan ML, Cook IA, Rapkin AJ, Leuchter AF. Estrogen augmentation of antidepressants in perimenopausal depression: a pilot study. Clin Psychiatry. 2005;66(6):774–80.
Nagata H, Nozaki M, Nakano H. Short-term combinational therapy of low-dose estrogen with selective serotonin re-uptake inhibitor (fluvoxamine) for oophorectomized women with hot flashes and depressive tendencies. J Obstet Gynaecol Res. 2005;31(2):107–14.
Papakostas GI, Thaseb ME, Favaa CM, Nelsond JC, Sheltone RC. Are antidepressant drugs that combine serotonergic and noradrenergic mechanisms of action more effective than the selective serotonin reuptake inhibitors in treating major depressive disorder? A meta-analysis of studies of newer agents. Biol Psychiatry. 2007;62(11):1217–27.
Papakostas GI, McGrath P, Stewart J, Charles D, Chen Y, Mischoulon D, Dording C, Fava M. Psychic and somatic anxiety symptoms as predictors of response to fluoxetine in major depressive disorder. Psychiatry Res. 2008;161(1):116–20.
Berlanga C, Flores-Ramos M. Different gender response to serotonergic and noradrenergic antidepressants. A comparative study of the efficacy of citalopram and reboxetine. J Affect Disord. 2006;95(1–3):119–23.
Bryant DN, Sheldahl LC, Marriott LK, Shapiro RA, Dorsa DM. Multiple pathways transmit neuroprotective effects of gonadal steroids. Endocrine. 2006;29(2):199–207.
Pae CU, Mandelli L, Kim TS, et al. Effectiveness of antidepressant treatments in pre-menopausal versus post-menopausal women: a pilot study on differential effects of sex hormones on antidepressant effects. Biomed Pharmacother. 2009;63(3):228–35.
Stewart DE, Rolfe DE, Robertson E. Depression, estrogen, and the Women’s Health Initiative. Psychosomatics. 2004;45(5):445–7.
Zanardi R, Rossini D, Magri L, Malaguti A, Colombo C, Smeraldi E. Response to SSRIs and role of the hormonal therapy in post-menopausal depression. Eur Neuropsychopharmacol. 2007;17(6–7):400–5.
Carretti N, Florio P, Bertolin A, Costa CV, Allegri G, Zilli G. Serum fluctuations of total and free tryptophan levels during the menstrual cycle are related to gonadotrophins and reflect brain serotonin utilization. Hum Reprod. 2005;20(6):1548–53.
Vadakkadath Meethal S, Atwood CS. The role of hypothalamic-pituitary-gonadal hormones in the normal structure and functioning of the brain. Cell Mol Life Sci. 2005;62(3):257–70.
Joyce PR, Mulder RT, Luty SE, Sullivan PF, McKenzie JM, Abbott RM, Stevens IF. Patterns and predictors of remission, response and recovery in major depression treated with fluoxetine or nortriptyline. Aust N Z J Psychiatry. 2002;36(3):384–91.
Pinna G, Costa E, Guidotti A. SSRIs act as selective brain steroidoenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Curr Opin Pharmacol. 2009;9:24–30.
Porcu P, O’Buckley T, Alward S, et al. Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5β neuroactive steroids in human and rat serum. Steroids. 2009;74:463–73.
Kornstein SG, Clayton AH, Soares CN, Padmanabhan SK, Guico-Pabia CJ. Analysis by age and sex of efficacy data from placebo-controlled trials of desvenlafaxine in outpatients with major depressive disorder. J Clin Psychopharmacol. 2010;30(3):294–9.
Cuijpers P, Weitz E, Twisk J, et al. Gender as predictor and moderator of outcome in cognitive behavior therapy and pharmacotherapy for adult depression: an “individual patient data” meta-analysis. Depress Anxiety. 2014;31(11):941–51.
Olgiati P, Bajo E, Bigelli M, Montgomery S, Serretti A, C.E.A.P. Group. Challenging sequential approach to treatment resistant depression: cost-utility analysis based on the Sequenced Treatment Alternatives to Relieve Depression (STAR D) trial. Eur Neuropsychopharmacol. 2013;23(12):1739–46.
Khan A, Brodhead AE, Schwartz KA, Kolts RL, Brown WA. Sex differences in antidepressant response in recent antidepressant clinical trials. J Clin Psychopharmacol. 2005;25(4):318–24.
Pae CU, Mandelli L, Kim TS, Han C, Masand PS, Marks DM, Patkar AA, Steffens DC, De Ronchi D, Serretti A. Effectiveness of antidepressant treatments in pre-menopausal versus post-menopausal women: a pilot study on differential effects of sex hormones on antidepressant effects. Biomed Pharmacother. 2009;63(3):228–35.
Phyllis T. A developmental line of gender identity role and choice of love of subject. Am Psychoanal Assoc J. 1986;30:61–86.
Gruenberg AM, Goldstein RD. Mood disorders: depression. In: Rasman A, Kay J, Lieberman JA, editors. Psychiatry, vol. 2. 2nd ed. Chichester: Wiley; 2003. p. 1207–36.
Beck AT. Cognitive therapy and the emotional disorders. New York: Meridian; 1976.
Abramson LY, Metalsky GI, Alloy LB. Hopelessness depression: a theory-based subtype of depression. Psychol Rev. 1989;96:358–72.
Seligman MEP. Helplessness: on depression, development, and death. San Francisco, CA: W.H. Freeman; 1975.
DeRubeis RJ, Evans MD, Hollon SD, Garvey MJ, Grove WM, Tuason VB. How does cognitive therapy work? Cognitive change and symptom change in cognitive therapy and pharmacotherapy for depression. J Consult Clin Psychol. 1990;58:862–9.
Agency for Health Care Policy and Research Depression Guideline Panel. Depression in primary care. vol. 2. Treatment of major depression (Clinical Practice Guideline No. 5; ACHPR Publication No. 93-0551). Rockville, MD: U.S. Department of Health and Human Services, Public Health Service; 1993.
Elkin I, Shea MT, Watkins JT, Imber SD, Sotsky SM, Collins JF, Glass DR, Pilkonis PA, Leber WR, Docherty JP, et al. National Institute of Mental Health Treatment of Depression Collaborative Research Program. General effectiveness of treatments. Arch Gen Psychiatry. 1989;46(11):971–82.
Angold A, Costello EJ, Worthman CM. Puberty and depression: the roles of age, pubertal status, and pubertal timing. Psychol Med. 1998;28:51–61.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Pérez Martinez de Arrieta, P., Gaviña Arenaza, J. (2019). Affective Disorders and Gender Differences. In: Sáenz-Herrero, M. (eds) Psychopathology in Women. Springer, Cham. https://doi.org/10.1007/978-3-030-15179-9_26
Download citation
DOI: https://doi.org/10.1007/978-3-030-15179-9_26
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-15178-2
Online ISBN: 978-3-030-15179-9
eBook Packages: MedicineMedicine (R0)