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Membrane-Containing Icosahedral Bacteriophage PRD1: The Dawn of Viral Lineages

  • Hanna M. OksanenEmail author
  • Nicola G. A. AbresciaEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1215)

Abstract

Membrane-containing enterobacterial phage PRD1 was isolated from sewage more than 40 years ago. At that time none would have expected the impact that unravelling its biology would have on modern virology and on the way we understand virus assembly, evolution and classification today. PRD1 structural analyses have provided a framework for understanding some aspects of virus evolution—introducing the concept of “viral lineages”—where the three-dimensional structures of virus capsids represent the fingerprint for evolutionary relationship which cannot be traced from the sequence data. In this review we summarise those findings that have led to the notion of viral lineages and the multidisciplinary efforts made in elucidating PRD1 life cycle. These studies have rendered PRD1 a model system not only for the family Tectiviridae to which it belongs, but more generally to complex DNA viruses enclosing a membrane vesicle beneath the capsid shell.

Keywords

Viral lineage PRD1 Adenovirus 3D structure Bacteriophage Tectiviridae Assembly Packaging DNA ejection Uncoating 

Notes

Acknowledgments

We are grateful to Stavros Azinas and Ralf Richter for the collaborative work on virus mechanics and Dennis Bamford for insightful comments on the review. We also thank Juliet Cowper for language editing. This study was supported by the Spanish Ministerio de Economía y Competitividad (MINECO/FEDER BFU2015-64541-R), by the Basque Departamento de Desarrollo Económico e Infraestructuras (Ref: 37-2017-00036) and Departamento de Educación, Política Lingüística y Cultura (Ref: PRE_2016_2_0151) to N.G.A.A. H.M.O was supported by the University of Helsinki and Academy of Finland funding for Instruct-FI research infrastructure and Biomolecular Complex Purification (BioComplex) core facility. We thank MINECO for the Severo Ochoa Excellence Accreditation to the CIC bioGUNE (SEV-2016-0644).

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research ProgrammeUniversity of HelsinkiHelsinkiFinland
  2. 2.Molecular Recognition and Host-Pathogen Interactions ProgrammeCIC bioGUNE, CIBERehdDerioSpain
  3. 3.IKERBASQUE, Basque Foundation for ScienceBilbaoSpain

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